The frequency of cytogenetic abnormalities in idiopathic oligospermia and azoospermia infertile men in Chaharmahal and Bakhtiari province: a cross-sectional study
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_SKUMS-22-1_002
تاریخ نمایه سازی: 28 آذر 1400
Abstract:
Background and aims: Infertility is one of the main health issues in families worldwide. In addition, there is a complex correlation betweengenetics and infertility and chromosomal abnormalities are found in ۸% of infertile males. The aim of this study was to determine thefrequency of cytogenetic abnormalities among idiopathic oligospermia and azoospermia infertile men who were treated in Chaharmahaland Bakhtiari province.Methods: In this cross-sectional study, the records of a total of ۱۰۰ participants were evaluated retrospectively. The patients who were undercareful physical and para-clinical (i.e., hormonal, ultrasound, and spermiogeram) examinations were enrolled in the study. Chromosomalanalysis was carried out on the cultures of peripheral blood lymphocytes by Giemsa (G) banding. Eventually, ۱۰ well-spread metaphaseswere analyzed by G-banding.Result: The chromosome abnormality frequency, the numerical type, and the structural type were ۱۳%, ۳%, and ۱۰%, respectively. Amongpatients with azoospermia, two cases had Klinefelter syndrome with karyotype.Conclusion: This study demonstrated that structural abnormalities are more prevalent than numerical abnormalities in infertile men whowere treated in Chaharmahal and Bakhtiari province. This indicates the importance of cytogenetic examination and the relevance of itsachievements to the patient’s management in infertility clinics. Therefore, the cytogenetic test is proposed for infertile men, in particular inthose who endure azoospermia.
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Authors
Hamideh Jafari-Ghahfarokhi
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
Delnya Gholami
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
Mohammad Rajaie Esfahani
Department of Urology, Shahrekord University of Medical Sciences, Shahrekord, Iran
Hossein Teimori
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran