Ameneh Bakhtiari - Department of Biology, Shahid Chamran University, Ahvaz, Iran
Amir Cheshmi - Department of Materials Engineering, Babol Noshirvani University of Technology, Shariati Avenue, Babol, Iran
Maryam Naeini - School of Nursing and Midwifery, Tehran University of Medical Science, Tehran, Iran
Sobhan Mohammadi Fathabad - Department of Engineering and High-Tech, Iran University of Industries and Mines, Tehran, Iran
Maryam Aliasghari - Young Researchers and Elite Club, Yadegar-e-Imam Khomeini (RAH) Shahr-e-Rey Branch, Islamic Azad University, Tehran, Iran
Amir Modarresi Chahardehi - Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, ۱۳۲۰۰, Kepala Batas, Penang, Malaysia

In this research, the ۸۰S bioactive glass with different Ca/P ratios was prepared by the sol-gel route. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Fourier transforms infrared spectroscopy (FTIR) were used to study the apatite structure and shape. According to the results, the ۷۸SiO۲–۱۷P۲O۵–۵CaO bioglass showed a higher rate of crystalline hydroxyapatite (HA) on its surface in comparison with the other bioglasses. After ۳ days of immersion in the SBF solution, spherical apatite was formed on the ۷۸SiO۲–۱۷P۲O۵–۵CaO surface, which demonstrated high bioactivity. A statistically significant promotion in proliferation and differentiation of G۲۹۲ osteoblastic cells was also observed. Regarding its optimal cell viability and bioactivity, the ۷۸SiO۲–۱۷P۲O۵–۵CaO bioactive glass could be offered as a promising candidate for bone tissue applications.

Bioactive glass, ۸۰S, Ca/P ratio, Hydroxyapatite