Yasamin Zamani - Department of Biology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
Ali Zareein - Department of Biomedical Engineering, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Leila Bazli - School of Metallurgy and Materials Engineering, Iran University of Science and Technology, Tehran, Iran
Reyhaneh NasrAzadani - Department of Biomaterials Nanotechnology and Tissue engineering, School of Advanced Technology in Medicine, Isfahan University of MedicalSciences, Isfahan, Iran
Babar Pasha Mahammod - National Institute of Technology Warangal, Warangal, India
Shima Nasibi - Department of Materials Science and Engineering, School of Engineering, Shiraz University, Shiraz, Iran

Due to promising properties such as low toxicity against different cell lines, being highly stable fluorescent without showing photobleaching, and good surface properties, nanodiamonds have gained ever-increasing attention for various biomedical applications including bioimaging and therapeutic applications. Various methods are used for the fabrication of nanostructured diamond, the commonly used of which is the denotation technique. Newer approaches are being practiced for the modification and functionalization of their surfaces by different biomolecules suitable for interaction with considered targets. In this review, the scope and recent advancement in the field of nanodiamonds for biomedical applications particularly their application for nanocomposite scaffold and implants are discussed.

Nanodiamonds, Surface modification, Biomedical application, Nanocomposite scaffold, Implants