Hasan Karami - Department of Pediatric Gastroenterology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Sahar Borna - General Practitioner, Mazandaran University of Medical Sciences, Sari, Iran
Fatemeh Hosseinzadeh - Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran,
Elahe Mahmoodi - Master in statistics, Birth cohort study center, Mazandaran university of medical sciences. Sari, Iran
Bahareh Lashtoo Aghaee - Assistant professor of Medical Bacteriology, Ramsar Campus, Mazandaran University of Medical Science, Ramsar, Iran. b.aghaee@mazums.ac.ir
Mohammad Sadegh Rezai - Associate Professor, Research Center with Focus on Nosocomial Infection, Bouali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran

Background: One of the most common food allergies in infants is cow’s milk allergy (CMA). There is no available effective therapeutic strategy for this issue. It's important to develop effective approaches to reduce the risk of cow’s milk allergy. The purpose of this study was to investigate the effect of probiotics on the infants with cow’s milk protein intolerance.Methods: This study was a randomized clinical trial in full-term infants with CMA diagnosis. These patients were divided into case and control groups (receiving placebo and probiotics). Clinical symptoms such as diarrhea, abdominal pain, etc. were evaluated in ۲, ۴, ۸, ۱۲ and ۱۶ weeks after receiving probiotics.Results: During the ۱۶ weeks of the study, a significant decrease was observed in the clinical and paraclinical findings in both groups. There was a statistically significant decrease in times of mucosal, bloody and daily defecation of the patients on the ۴th, ۸th and ۱۲th weeks. Also, a significant difference was found between the groups in diarrhea and abdominal cramps from the ۴th week.Conclusion: The consumption of probiotics for a short time in infants with CMA significantly decreased the clinical and paraclinical symptoms.

cow’s milk allergy, Diarrhea, Infant, Probiotics