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Title

Interval Intensity Exercise Improves the Levels of Mitophagy-related Proteins and ROS in Rats with Myocardial Infarction

مجله علوم ورزشی و سلامت، دوره: 1، شماره: 2
Year: 1400
COI: JR_JEHS-1-2_002
Language: EnglishView: 35
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Authors

Babak Ebadi - Cardiovascular Department of Sport Sciences faculty, Guilan University of Iran
Nasim Naderi - Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Amir Darbandi Azar - Veterinary Surgeon, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Arsalan Damirchi - Professor, Dept. of Cardiovascular Exercise Physiology, facultyof Exercise Sciences, Guilan University, Rasht, Iran

Abstract:

Background & Objectives: Myocardial infarction (MI) is a common heart disease in humans, and mitochondrial dysfunction has been implicated in its development. Exercising plays a protective role against the disease; however, the role of certain proteins and mitophagy is not well understood. The aim of this study was to investigate the effects of exercise intensity on the levels of mitochondrial proteins and reactive oxygen species (ROS) in the heart tissue of male rats post MI. Materials & Methods: We induced MI in ۴۰ male Wistar rats by ligating left anterior descending artery. Animals were divided into five groups as follows: three exercise groups (high, moderate & low) post MI, one sedentary group post MI, and one control group without MI or exercising. The levels of P۶۲ and Parkin proteins, and ROS were determined in the heart tissue by ELISA and DCFDA methods.Results: Data analysis showed the levels of free P۶۲ and Parkin proteins decreased significantly in the sedentary group compared to those in the controls (P≤۰.۰۵). The cardiac tissue ROS level decreased significantly in the moderate intensity group compared to that in the sedentary group, but it increased compared to that of the control group (P≤۰.۰۵).Conclusions: Moderate-intensity exercise significantly increased the levels of free P۶۲ and Parkin proteins and reduced the ROS in the heart tissue post MI. The findings support the hypothesis that improvements in the levels of ROS and proteins involved in the mitophagy are stimulated by performing moderate intensity exercises

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This Paper COI Code is JR_JEHS-1-2_002. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1355925/

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Ebadi, Babak and Naderi, Nasim and Darbandi Azar, Amir and Damirchi, Arsalan,1400,Interval Intensity Exercise Improves the Levels of Mitophagy-related Proteins and ROS in Rats with Myocardial Infarction,https://civilica.com/doc/1355925

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Type of center: دانشگاه دولتی
Paper count: 14,991
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