Abdul Rahman Akkawi - Department of Clinical Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
Lynn Ezzeddine - Department of Diagnostic Radiology, Saint George Hospital University Medical Center, University of Balamand, Beirut, Lebanon
Rita Chahinian - Department of Clinical Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
Firas Ershaid - Department of Clinical Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
Diala Merheb - Department of Clinical Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
Majd Mzeihem - Department of Clinical Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon
Jean El Cheikh - Department of Internal Medicine, Division of Hematology/Oncology, American University of Beirut Medical Center, Beirut, Lebanon
Mohamad Haidar - Department of Clinical Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon

۱۸F-Flurodeoxyglucose (FDG) PET/CT has been considered the modality of choice in detecting, staging, restaging and following-up with lymphoma patients. However, it has an uncertain role in differentiating hepatic lymphomatous relapse from other granulomatous diseases such as in candidiasis or sarcoidosis. Therefore, it is important to correlate the imaging findings with other modalities such as ultrasound, CT scan, MRI, and histology to direct the diagnosis and treatment. We present a case of a ۳۳-year-old woman with large B-cell lymphoma in complete remission following treatment presenting with neutropenic fever following her final cycle of chemotherapy. Ultrasound of the abdomen and enhanced CT scan of the abdomen and pelvis were negative. The FDG PET/CT scan showed multiple FDG-avid hypodense hepatic lesions that were suggestive either of lymphoproliferative involvement or nonmalignant process. However, MRI of the abdomen performed four days later was suggestive of an infectious process, rather than a lymphoproliferative disorder. A subsequent CT-guided biopsy of a hepatic lesion showed granulomatous inflammation, with no evidence of malignancy or Tuberculosis. The patient was started on Caspofungin followed by Fluconazole. After ۵ weeks, the clinical condition resolved, and the subsequent FDG PET/CT showed complete resolution of the FDG-avid multiple hepatic lesions.

F-۱۸ PET CT, large B cell lymphoma, Hepatic granuloma, hepatic candidiasis