AQSAR St udy on Bi ological Activities of Diketo C ompound s as HIV-۱ integrase inhibitors

Human immunod eficiency v irus type ۱ (HIV-۱) is the prima ry cause ofacquired im muno-defici ency syndr ome (AIDS ) a slow,progressive an d degenera tive disease of the human immune system that has been one of the world, s most serious health problems since ۱۹۸۱. In recent years, HIV-۱ integrase (IN) has become an attractive target for designing anti-re troviral agents .In this work quantitative structure activi ty relationship (QSAR) study has been done on diketoanalogues acting a s HIV-۱ integrase inhibitors.G enetic algorithm(GA),artificialneural network ( ANN),multiple linear regressions( MLR) were used to cre ate the nonlinear and lin ear QSAR models[۱-۳].

Keywords:

QSAR , Diketo acid , Diketoester , Genetic algorithm , HIV-۱inhibitor