P hysical Chemistry Study of L nEmLn Block Copolymeric M icelles fo r Protein Delivery

Biodegradable, p olymer-based micro-/nanoparticles are attractiv e drug delivery system s for therapeutics with high pharm acological potential [۱-۴]. We have previously s tudied polymeric vesicles of a biodegradable triblock c opolymer composed of polyethylene glycol and poly(fumaric aci d- co- seba coyl chloride) (PEG- co-P(FA/SC)-co-PEG) and reporte d its inertness against insulin [۵]. Here a series of biodegr adable triblo ck copolymers made of PEG and p oly (L-lactid e) (LnEmLn ), with new and differe nt molecular weights are used to prepare micro-/nanoparticles. The ai m is to inv estigate on the physicochemical properties o f the copol ymers as well as of the resulting micelles. The n, the effect of the L۳۷E۱۳۶L۳۷ copolymer on the structure of bovine insu lin will be e valuated in details.

Keywords:

Triblo ck copolymer , Nanoparticle , Biode gradable , Insulin.