Study on the potency of domperidone and metoclopramide for spawning induction in Kutum (Rutilus frisii kutum )

Publish Year: 1385
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JIFRO-6-2_007

تاریخ نمایه سازی: 13 دی 1400

Abstract:

The effectiveness of two kinds of dopamine antagonist (DA), metoclopramide (Met) and domperidone (Dom) combined with the gonadotropin releasing hormone analogue (D-Ala۶, Des Gly۱۰ ethylamide) GnRHa was assayed on the ovulation success, latency period, ovulation index (OI) and fertilization success of kutum, Rutilus frisii kutum (Kamenskii, ۱۹۰۱). Brood fish were injected intra-peritoneally as follows: ۲ mg/kg b.w. of carp pituitary extract (CPE) as a control, ۵ g+ ۲.۵mg, ۱mg+ ۵mg and ۲mg+ ۱۰mg/kg b.w. of GnRHa + Met or Dom in a single injection. Based on the ovulation and fertilization success, no significant differences between similar doses of Dom and Met when combined with similar doses of GnRHa were found (p>۰.۰۵). However, in some groups, the OI and latency period were greater when Dom was used as a DA instead of Met (p<۰.۰۵). In general, the results of this study showed that the potency of Dom was nearly same as Met when combined with GnRHa and used as a DA in kutum. It is strongly recommended to repeat the experiment under different conditions to find out definite conclusion.