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Title

Enhanced in vitro cytotoxicity and intracellular uptake of Genipin via loaded on Nano-Liposomes made from soy lecithin in MCF-۷ cells

مجله علوم نانو، دوره: 9، شماره: 1
Year: 1401
COI: JR_NAMJ-9-1_007
Language: EnglishView: 31
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Authors

Tahereh Naseriyeh - Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Tayebeh Noori - Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Hosna Alvandi - Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Hossein Zhaleh - Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Leila Behbood - Pharmaceutical Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Alireza Shamsi - Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Faranak Aghaz - Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Elham Arkan - Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract:

Objective(s): As an alternative to chemical drugs, natural compounds such as Genipin can reduce toxicity and side effects. In recent years, Genipin's antioxidant properties have been considered a potential cancer treatment. Therefore, the present study investigated anti-cancer activity of newly formulated nano-liposomal loaded Genipin, made from soy lecithin, against MCF-۷ cancer cell line. Materials and Methods: After synthesis, the physicochemical properties of the liposomes were confirmed by Dynamic light scattering (DLS), Scanning Electron Microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and UV-vis spectrophotometry. Results: Our results showed that the prepared nano-liposome had a diameter of ۱۶۶.۲ nm. Its Zeta potential was -۲۵.۴ mV which indicates the good electrostatic stability of nano-liposomes. Also, a slight size distribution (PDI ۰.۲۸۷۰) and a high encapsulation efficiency (EE% >۸۲% and DL>۲۸%) are other features of synthesized nano-liposomal loaded Genipin. The in vitro result profile demonstrated that the drug-controlled release from Genipin loaded-liposomal is ۶۵% during ۷۰h. The in vitro cytotoxic activity of nano-liposomal loaded Genipin in comparison with free Genipin, was explored on MCF-۷ cell line using MTT colorimetric assay. Our results revealed that the IC۵۰% (cytotoxicity) of MCF-۷ cells treated with nano-liposomes loaded Genipin were higher than those treated with free Genipin (about ۲.۴ orders of magnitude). Additionally, cell uptake studies evidenced a higher uptake of negative nano-liposomal loaded Genipin. Conclusion: In a nutshell, newly formulated nano-liposomal is an ideal vehicle for negative targeting (anticancer effect) of drugs to tumor cells that may result in improved efficacy and reduced toxicity of encapsulated drug moiety.

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This Paper COI Code is JR_NAMJ-9-1_007. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

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Naseriyeh, Tahereh and Noori, Tayebeh and Alvandi, Hosna and Zhaleh, Hossein and Behbood, Leila and Shamsi, Alireza and Aghaz, Faranak and Arkan, Elham,1401,Enhanced in vitro cytotoxicity and intracellular uptake of Genipin via loaded on Nano-Liposomes made from soy lecithin in MCF-۷ cells,https://civilica.com/doc/1372015

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Type of center: علوم پزشکی
Paper count: 1,919
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