The Efficacy and Safety of Iodine-۱۲۵ Implantation Combined with Gemcitabine in the Treatment of Advanced Pan- creatic Cancer: A Systematic Review and Meta-analysis
عنوان مقاله: The Efficacy and Safety of Iodine-۱۲۵ Implantation Combined with Gemcitabine in the Treatment of Advanced Pan- creatic Cancer: A Systematic Review and Meta-analysis
شناسه ملی مقاله: JR_MCIJO-5-3_002
منتشر شده در در سال 1400
شناسه ملی مقاله: JR_MCIJO-5-3_002
منتشر شده در در سال 1400
مشخصات نویسندگان مقاله:
Jingxin Yan - Department of Interventional Therapy, Affiliated hospital of Qinghai University, Xining, China & Department of Postgraduate, Qinghai University, Xining, China
Ting Li - Department of Orthopedics, Sichuan People's Hospital, Chengdu, China & Department of Postgraduate, Chengdu Medical College, Chengdu, China
Yaxuan Wang - Department of Radiology, Chengdu Medical College, Chengdu, China
Hao Zhu - Department of Ultrasound Medicine, People’s Hospital of Tibet Autonomous Region, Lhasa, China ; Department of Postgraduate, Tibet University, Lhasa, China
Ruihong Liu - Nanchong Central Hospital, North Sichuan Medical College, Nanchong, China
Zhenwu Lei - Department of Interventional Therapy, Affiliated hospital of Qinghai University, Xining, China
Yingxing Guo - Department of Interventional Therapy, Affiliated hospital of Qinghai University, Xining, China
خلاصه مقاله:
Jingxin Yan - Department of Interventional Therapy, Affiliated hospital of Qinghai University, Xining, China & Department of Postgraduate, Qinghai University, Xining, China
Ting Li - Department of Orthopedics, Sichuan People's Hospital, Chengdu, China & Department of Postgraduate, Chengdu Medical College, Chengdu, China
Yaxuan Wang - Department of Radiology, Chengdu Medical College, Chengdu, China
Hao Zhu - Department of Ultrasound Medicine, People’s Hospital of Tibet Autonomous Region, Lhasa, China ; Department of Postgraduate, Tibet University, Lhasa, China
Ruihong Liu - Nanchong Central Hospital, North Sichuan Medical College, Nanchong, China
Zhenwu Lei - Department of Interventional Therapy, Affiliated hospital of Qinghai University, Xining, China
Yingxing Guo - Department of Interventional Therapy, Affiliated hospital of Qinghai University, Xining, China
Introduction: A systematic review and meta-analysis was conducted to assess the efficacy and safety of iodine-۱۲۵ implantation combined with gemcitabine in the treatment of advanced pancreatic cancer.
Methods: PubMed, Chinese National Knowledge Infrastructure database (CNKI), Cochrane Library, Embase, and Wanfang database through Oct ۲۰۲۰ were searched
for randomized controlled trials (RCTs) and retrospective studies assessing the efficacy
and safety of iodine-۱۲۵ implantation combined with gemcitabine in the treatment of advanced pancreatic cancer. The main outcome measures included the overall remission [complete response (CR)+partial response (PR)] rate, overall survival (OS), hypofunction of the liver, clinical benefit response (CBR) rate, survival rate, and adverse events.
Results: Totally, ۱۹ studies involving ۱۴۹۶ patients were included in the current systematic review and meta-analysis. The pooled results showed that efficacy and safety of patients treated with Iodine-۱۲۵ combined with gemcitabine were superior to those undergoing gemcitabine alone: overall remission (CR+PR) rate [odds ratio (OR)=۳.۱۰, ۹۵% confidence interval (CI): ۲.۴۰, ۴.۰۰; P<۰.۰۰۰۰۱], OS [hazard ratio (HR)=۰.۵۶, ۹۵% CI: ۰.۴۷, ۰.۶۸; P<۰.۰۰۰۰۱], hypofunction of liver (OR=۱.۰۸, ۹۵% CI: ۰.۶۷, ۱.۷۴;
P=۰.۷۵), CBR rate (OR=۳.۸۵, ۹۵% CI: ۲.۸۳, ۵.۲۲; P<۰.۰۰۰۰۱), survival rate of six months (OR=۳.۴۴ ۹۵% CI: ۱.۸۳, ۶.۴۶) and survival rate of ۱۲ months (OR=۲.۶۷, ۹۵% CI: ۱.۶۸, ۴.۲۶). And there was no statistical association in adverse events between the groups.
Conclusions: The combination of iodine-۱۲۵ seed implantation and gemcitabine significantly prolonged the survival of patients with pancreatic cancer, compared with the gemcitabine alone, indicating a better prognosis.
کلمات کلیدی: Iodine-۱۲۵, Pancreatic Neoplasms, Meta-Analysis, Gemcitabine
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1377190/