Maternal polymorphic loci of rs۱۹۷۹۲۷۷ serine hydroxymethyl transferase and rs۱۸۰۵۰۸۷ ۵-methylenetetrahydrofolate are correlated with the development of fetal growth restriction: A case-control study

Background: Key reactions in folate-mediated single-carbon metabolism are regulated by folate cycle enzymes. Violations of the folate cycle may be associated with the occurrence of fetal growth restriction (FGR) in pregnant women. Objective: To study the relationship between polymorphisms of folate cycle genes in the mother with the development of FGR. Materials and Methods: In this case-control study, ۱۲۲ pregnant women with FGR and ۲۴۳ pregnant women with normal newborn weight were enrolled. The polymorphic loci of folate cycle genes including rs۱۸۰۵۰۸۷ ۵-methylenetetrahydrofolate (MTR) and rs۱۹۷۹۲۷۷ serine hydroxymethyl transferase (SHMT۱) were examined. The study of polymorphisms was carried out through the TaqMan probe detection method using polymerase chain reaction. Logistic regression was used to analyze the associations of the polymorphisms. Results: It was established that the T allele rs۱۹۷۹۲۷۷ of the SHMT۱ gene was correlated with the development of FGR within the framework of the allelic (OR = ۱.۶۷, ۹۵% CI ۱.۲۰-۲.۳۳, pperm < ۰.۰۱), additive (OR = ۱.۶۹, ۹۵% CI ۱.۲۰-۲.۳۷, pperm < ۰.۰۱), dominant (OR = ۱.۸۱, ۹۵% CI ۱.۱۵-۲.۸۷, pperm = ۰.۰۱) and recessive (OR = ۲.۳۴, ۹۵% CI ۱.۱۵-۴.۷۳, pperm = ۰.۰۱) models. The association of the G rs۱۸۰۵۰۸۷ allele of the MTR gene with the occurrence of FGR was also identified following the recessive model (OR = ۳.۰۱, ۹۵% CI ۱.۰۵-۸.۶۸, pperm = ۰.۰۴). Conclusion: Our results indicated that maternal polymorphic loci rs۱۹۷۹۲۷۷ SHMT۱ and rs۱۸۰۵۰۸۷ MTR may be associated with the development of FGR.

Keywords:

Polymorphism , Associations , Fetal growth restriction , Folic acid. , پلی مورفیسم , ارتباط , محدودیت رشد جنین , اسید فولیک.