Effectiveness Analysis of Triptorelin, Goserelin, and Leuprolide in the Treatment of Patients with Metastatic Prostate Cancer

Introduction: Metastatic prostate cancer is the most common malignant cancer and the second leading cause of death due to various types of cancer among men after lung cancer. The aim of this study was to analyze the effectiveness of Triptorelin, Goserelin, and Leuprolide in the treatment of the patients with metastatic prostate cancer in southern Iran in ۲۰۲۰. Methods: This is a cross-sectional descriptive-analytical study that was performed in ۲۰۲۰ on patients with metastatic prostate cancer who referred to clinics under the auspices of Shiraz University of Medical Sciences and were treated with Goserelin, Triptorelin and Leuprolide. In this study, they were selected through census, the effectiveness was obtained as the success rate of treatment. Excel ۲۰۱۶ and SPSS software were used to analyze the collected data. Results: In this study, ۱۵۳ patients participated. The mean age of patients with metastatic prostate cancer treated with Leuprolide, Triptorelin and Goserelin was ۷۱.۴, ۷۳.۲ and ۷۲.۷ years, respectively. Most patients in all three drug groups (۴۳.۱%, ۴۵.۱% and ۴۵.۱%) had social security insurance coverage. The results showed that, the success of treatment with Goserelin, Triptorelin, and Leuprolide was ۰.۷۵, ۰.۶۷, and ۰.۶۱, respectively. Conclusion: According to the results of this study, Goserelin was a more effective strategy than the other two options. Therefore, it is recommended to service providers to prescribe this drug, and insurance organizations are also suggested to cover it.

Keywords:

Effectiveness , Metastatic Prostate cancer , Goserelin , Triptorelin , Leuprolide