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Title

Synthesis of silver nanoparticles and hybridization with Bovine serum albumin nanoparticles as a nanocarrier for quercetin and investigation of its anticancer effects on ۴T۱ cell line

پنجمین کنگره بین المللی سرطان
Year: 1400
COI: CANCERMED05_156
Language: EnglishView: 110
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Mahmud Gharbavi - Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
Ali Sharafi - Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
Roghayeh Ghorbani - Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Behrooz Johari - Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Abstract:

Introduction:In women, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death. The anti-cancer effects of quercetin (Que) such as cellular signaling, apoptosis, anti-proliferation, anti-oxidant and growth suppression have been reported by several studies. On the other hand, treatment with anti-cancer nanodrugs causes the drug to accumulate in tumor tissue, minimizing drug interactions in off-target tissue, ameliorating direct effects, and inhibiting indirect effects and side effects. Silver nanoparticles have attracted a considerable interest in the field of cancer research due to their potential utility in cancer therapy.Materials and Methods:In the present study, we developed Ag NPs hybrid with BSA Nps (Ag@BSA NPs) and characterized in vitro therapeutic activities of this NPs for the treatment of breast cancer. Ag@BSA NPs were synthesized by a single-step reduction process, and the successful preparation was verified through a list of physical characterizations, including SEM, EDX, UV spectroscopy and DLS. These Ag@BSA@QUE NPs also demonstrated sustained release of QUE at ۳۷ °C in different buffer solutions.Results:The Ag@BSA@QUE NPs showed significant anti-cancer effects on ۴T۱ cells. These NPs decreased cell proliferation as well as increased apoptosis, which may have been caused by oxidative stress.Conclusion:It can be concluded that Ag@BSA@QUE NPs could potentially suppress the cancerous properties of ۴T۱ cells and the presented nanocarrier system can be a promising approach for targeted drug delivery in cancer treatment.

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This Paper COI Code is CANCERMED05_156. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1377903/

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Gharbavi, Mahmud and Sharafi, Ali and Ghorbani, Roghayeh and Johari, Behrooz,1400,Synthesis of silver nanoparticles and hybridization with Bovine serum albumin nanoparticles as a nanocarrier for quercetin and investigation of its anticancer effects on ۴T۱ cell line,Fifth International Cancer Congress,Tehran,https://civilica.com/doc/1377903

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Type of center: علوم پزشکی
Paper count: 1,084
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