Maternal aromatase inhibition via letrozole altered RFamide-related peptide-۳ and gonadotropin-releasing hormone expression in pubertal female rats

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
View: 236

This Paper With 11 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJBMS-25-1_015

تاریخ نمایه سازی: 2 بهمن 1400

Abstract:

Objective(s): Despite prevalence of polycystic ovary syndrome (PCOS) among childbearing women and development of many animal models for this syndrome, information on its etiology is still scarce. The intrauterine hyperandrogenic environment may underlie changes at the level of hypothalamus, pituitary, ovary organization in female offspring, and PCOS later in life. Letrozole has been shown to mimic reproductive and metabolic characteristics of PCOS in adult rodent models. Therefore, this research aimed to assess the condition in a prenatal letrozole-treated rat model. Materials and Methods: Twenty-eight female rats dams receiving letrozole at certain doses during late pregnancy were used in the trial.  Pregnant Sprague-Dawley rats (n=۲۱) received letrozole treatment on gestation days ۱۶–۱۸ at doses of ۱.۲۵, ۱.۰, ۰.۷۵, ۰.۵, and ۰.۲۵ mg/kg body weight (BW).    Results: Prenatal letrozole treatment delayed parturition time and reduced the litter size in pregnant dams (P<۰.۰۰۰۱). Late puberty onset, irregular ovarian cyclicity, increased anogenital distance (AGD), body weight gain, serum testosterone concentration, and reduced estradiol levels (P<۰.۰۰۰۱) were observed in the female offspring of dams receiving ۱.۲۵ and ۱ mg/kg BW letrozole. Furthermore, letrozole at ۱.۲۵ and ۱ mg/kg BW showed increased RFRP and decreased GnRH mRNA expression (P<۰.۰۰۰۱). Letrozole treatment at doses of ۱ mg/kg BW and lower was not fetotoxic. Conclusion: It was concluded that ۱ mg/kg BW letrozole may be suggested for prenatal PCOS induction. 

Keywords:

Authors

Zahra Shaaban

Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran

Amin Tamadon

The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran

Mohammad Reza Jafarzadeh Shirazi

Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran

Mohammad Javad Zamiri

Department of Animal Science, College of Agriculture, Shiraz University, Shiraz, Iran

Amin Derakhshanfar

Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. ...
  • Astapova O, Minor BMN, Hammes SR. Physiological and pathological androgen ...
  • Krentowska A, Kowalska I. Metabolic syndrome and its components in ...
  • Tamadon A, Hu W, Cui P, Ma T, Tong X, ...
  • Abruzzese GA, Heber MF, Ferreira SR, Ferrer MJ, Motta AB. ...
  • Kawwass JF, Sanders KM, Loucks TL, Rohan LC, Berga SL. ...
  • Paixão L, Ramos RB, Lavarda A, Morsh DM, Spritzer PM. ...
  • Kafali H, Iriadam M, Ozardali I, Demir N. Letrozole-induced polycystic ...
  • Mehdinejadiani S, Amidi F, Mehdizadeh M, Barati M, Safdarian L, ...
  • Steiner N, Shrem G, Tannus S, Dahan SY, Balayla J, ...
  • Yun J, Choi YS, Lee I, Won YB, Lee JH, ...
  • Bizzarri C, Cappa M. Ontogeny of hypothalamus-pituitary gonadal axis and ...
  • Patisaul HB. Endocrine disruption and reproductive disorders:impacts on sexually dimorphic ...
  • Ibanez L, de Zegher F, Potau N. Anovulation after precocious ...
  • Bakker J, Baum MJ. Role for estradiol in female-typical brain ...
  • Lephart ED. A review of brain aromatase cytochrome P۴۵۰. Brain ...
  • Vandenbergh JG, Huggett CL. The anogenital distance index, a predictor ...
  • Marcondes F, Bianchi F, Tanno A. Determination of the estrous ...
  • Chaudhari N, Dawalbhakta M, Nampoothiri L. GnRH dysregulation in polycystic ...
  • Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, ...
  • Feng Y, Johansson J, Shao R, Manneras L, Fernandez-Rodriguez J, ...
  • Han X, He Y, Zeng G, Wang Y, Sun W, ...
  • Esparza LA, Schafer D, Ho BS, Thackray VG, Kauffman AS. ...
  • Iwasa T, Matsuzaki T, Yano K, Mayila Y, Yanagihara R, ...
  • Aliabadi E, Namavar MR, Mortezaee K, Toolee H, Keshtgar S, ...
  • Osuka S, Iwase A, Nakahara T, Kondo M, Saito A, ...
  • Shaaban Z, Jafarzadeh Shirazi MR, Nooranizadeh MH, Tamadon A, Rahmanifar ...
  • Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kuwahara A, ...
  • Hafez ES, Kodituwakku GE. Postnatal development of the oviduct of ...
  • Semaan SJ, Kauffman AS. Daily successive changes in reproductive gene ...
  • Zurvarra FM, Salvetti NR, Mason JI, Velazquez MM, Alfaro NS, ...
  • Baravalle C, Salvetti NR, Mira GA, Pezzone N, Ortega HH. ...
  • Sir-Petermann T, Maliqueo M, Codner E, Echiburu B, Crisosto N, ...
  • Xu G, Zhang A, Liu J, Wang X, Feng J, ...
  • Tiboni GM, Ponzano A. Fetal safety profile of aromatase inhibitors: ...
  • Skarra DV, Hernández-Carretero A, Rivera AJ, Anvar AR, Thackray VG. ...
  • Torres PJ, Skarra DV, Ho BS, Sau L, Anvar AR, ...
  • Wu XY, Li ZL, Wu CY, Liu YM, Lin H, ...
  • Tehrani FR, Noroozzadeh M, Zahediasl S, Piryaei A, Hashemi S, ...
  • Caldwell AS, Middleton LJ, Jimenez M, Desai R, McMahon AC, ...
  • Sullivan SD, Moenter SM. Prenatal androgens alter GABAergic drive to ...
  • Tandulwadkar SR, Lodha PA, Mangeshikar NT. Obstetric complications in women ...
  • Birch RA, Padmanabhan V, Foster DL, Unsworth WP, Robinson JE. ...
  • Foecking EM, Szabo M, Schwartz NB, Levine JE. Neuroendocrine consequences ...
  • Manneras L, Cajander S, Holmäng A, Seleskovic Z, Lystig T, ...
  • Matsuzaki T, Tungalagsuvd A, Iwasa T, Munkhzaya M, Yanagihara R, ...
  • Arroyo P, Ho BS, Sau L, Kelley ST, Thackray VG. ...
  • Ryan GE, Malik S, Mellon PL. Antiandrogen treatment ameliorates reproductive ...
  • Agoreyo F, Okeke O. Quantitative evaluation of serum oestrogen levels ...
  • Kafali H, Iriadam M. A novel tocolytic agent: effects of ...
  • Tiboni G, Marotta F, Rossi C, Giampietro F. Effects of ...
  • Tiboni G, Marotta F, Castigliego A, Rossi C. Impact of ...
  • Boomsma C, Eijkemans M, Hughes E, Visser G, Fauser B, ...
  • نمایش کامل مراجع