Bijan Khademi - Department of Otorhinolaryngology, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
Behzad Khademi - Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.
Abbas Ghaderi - Department of Immunology, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyd Fakhroddin Hosseini - Department of Otorhinolaryngology, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
Nika Niknejad - Department of Otorhinolaryngology, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: The presence of HER-۲ has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-۲ in HNSCC and its correlation with various clinicopathologic parameters.   Materials and Methods: Peripheral blood samples were obtained from ۱۷ healthy volunteers and ۶۹ patients with HNSCC before curative surgery. The HER-۲ level was determined in each sample by sandwich ELISA. Statistical analysis was performed using an independent t-test, one-way ANOVA, and Mann-Whitney Test.   Results: Mean HER-۲ serum levels in patients with HNSCC compared with healthy controls was not statistically significant (۳.۸۵ng/ml vs. ۳.۷۵ng/ml; P>۰.۰۵). The mean serum level of HER-۲ was higher in patients with lymph node involvement, metastasis, invasion, tumor size ≥۲ cm, and stage>۱, although the differences were not statistically significant (P>۰.۰۵).   Discussion: Mean HER-۲ serum levels in patients with tumor size T۳ and higher were greater than those from patients in stage T۱ and T۲, a finding which may be translated into disease progression, growth and invasiveness.  Conclusion: In this study the mean HER-۲ serum level in patients with HNSCC was found statistically insignificant compared with the healthy control group. The role of soluble HER-۲ as a tumor marker is still controversial and needs further studies to clarify its clinical  relevance for early detection or screening for HNSCC.

HNSCC, Her-۲, EGFR, Tmor marker