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LncRNA SNHG۶ Silencing Could Arrest Progression of High Grade Colorectal Cancers

فصلنامه آسیب شناسی ایران، دوره: 17، شماره: 1
Year: 1401
COI: JR_IJP-17-1_005
Language: EnglishView: 35
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- - - Pathology and Stem Cell Research Center, Department of Pathology, Afzalipour Medical School, Kerman University of Medical Sciences, Kerman, Iran
- - - Pathology and Stem Cell Research Center, Department of Pathology, Afzalipour Medical School, Kerman University of Medical Sciences, Kerman, Iran
- - - Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology Kerman, Iran


Background & Objective: Colorectal cancer (CRC), like other cancers, needs faster and more accurate identifications. A well-timed prognosis of CRC could be an important turning point in the survival of patients. Supplementary signs, such as long non-coding RNAs (lncRNAs), could be helpful for this purpose. A new possible biomarker for CRC identification is introduced by this study.Methods:  RNA extraction was performed by the RNX-Plus solution for ۶۴ tumor and non-tumor tissues. Complementary DNAs (cDNAs) were synthesized, and quantitative real-time PCR was performed for relative expression level measurement and the data was analyzed statistically using the Prism ۶ software. For Small nucleolar host gene ۶ knockdown, siRNA was designed based on Reynolds rules. The cells were cultured in their appropriate media, and the siRNA-lipofectamine complex was formed. The transfection complex was presented for sw۴۸, sw۴۸۰, and sw۱۱۱۶ as CRC cells with different grades. After transfection, the SNHG۶/β actin ratio was determined. Then, the distribution of siRNA-treated cells was determined by the Partec flow cytometer instrument and analyzed by the FloMax software.Results: SNHG۶ was more expressed in CRC tumors than non-tumor tissues. In tumor tissues, SNHG۶ upregulation and tumors’ grade progression were concurrent. SNHG۶ was upregulated in cases with lymphovascular invasion than in cases with perineural invasion. The knockdown of SNHG۶ conduced to G۱ arrest in CRC cells, more noticeably in high-grade ones.Conclusion: SNHG۶ could be applied as a consideration to differentiate tumor and non-tumor tissues and grade definition in colorectal malignancies, and it could participate in colorectal tumor formation as a cell cycle progressive factor.


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