- - - Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- - - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases,Shahid Beheshti University of Medical Sciences, Tehran, Iran
- - - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases,Shahid Beheshti University of Medical Sciences, Tehran, Iran
- - - Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- - - Department of Pathology , School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- - - Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- - - Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- - - Department of Pathology , School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- - - University of Toronto, Department of Biology, Toronto, Canada

Background & Objective: Pancreatobiliary system disorders commonly include inflammatory diseases and tumors. Diagnosis of pancreatic cancer is challenging and is mostly achieved when the disease has extensively progressed, and metastasis has occurred. Therefore, this study was performed to evaluate cytopathology in the diagnosis of Pancreatobiliary malignancies, which can improve diagnostic adequacy and accuracy.Methods: A total of ۱۱۶ cytopathologic results of the Pancreatobiliary system, performed in the Pathology Department of Taleghani Hospital, Tehran, Iran during ۲۰۱۷-۲۰۱۸ were selected and examined in this observational study. The frequency of different results was determined and compared with other variables.Results: The most common location of the lesions was the pancreas (۴۷%). The lesions were categorized as malignant, benign, negative, suspicious for malignancy (SFM), and atypical in ۲۸%, ۱۰%, ۲۴%, ۱۴%, and ۹% of the cases, respectively. In other cases, lesions were considered non-diagnostic. Rapid on-site evaluation (ROSE) was conducted in ۲۵% of patients. Compatibility of the initial and final diagnoses was ۱۰۰%, ۵۰%, and ۶۰% in cases with “malignant”, “benign”, and “negative” diagnoses, respectively. The sensitivity, specificity, as well as positive and negative predictive values of cytopathology in the diagnosis of Pancreatobiliary lesions were ۷۵.۸%, ۹۲.۳%, ۹۵.۹%, and ۶۱.۵%, respectively. Conclusion: Our findings indicated that half of the lesions of the Pancreatobiliary system were positive, SFM, and atypical. Fine-needle aspiration (FNA) and endoscopic ultrasound-guided FNA (EUS-FNA) were effective modalities in diagnosing Pancreatobiliary malignancies. The most important point in our experience is the increase in diagnostic sensitivity in the presence of ROSE. Therefore, the simultaneous use of ROSE and EUS-FNA can reduce the need for re-sampling.

Cytopathology, Pancreatobiliary system, rose, Sensitivity, Specificity