Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RBMB-10-3_003
تاریخ نمایه سازی: 25 بهمن 1400
Abstract:
Background: Epilepsy is one of the most widespread neurological disease worldwide. Status epilepticus (SE) is a life-threatening neurologic disorder. Neuroprotective approaches are increasingly to discover a promising therapy to manage epileptic disorders. This study aimed to assess the impact of berberine on some epigenetic, transcription regulation & inflammatory biomarkers in a mice model of epilepsy.
Methods: This work was performed on; Group I: (control), Group II: berberine‐treated control, Group III: epilepsy group, Group IV: berberine‐treated epilepsy. Groups were subjected to assessment of Tumor growth factor-۱ꞵ (TGF-۱ꞵ), hypoxia inducible factor-۱α (HIF-۱α), brain derived neurotrophic factor (BDNF) levels, histone deacetylase (HDAC) activity & neuronal restrictive silencing factor (NRSF) gene expression.
Results: Study showed significant increase in levels of HIF-۱α, TGF-۱β, HDAC activity & NRSF gene expression in epilepsy group & decrease in these levels in berberine treated epilepsy group. Significant decrease in BDNF levels in epilepsy & elevation in them in berberine treated epilepsy group.
Conclusions: Our study showed the anti-epileptic impact of berberine via its regulatory effect on some epigenetic, transcription factors & inflammatory biomarkers in a mice model of epilepsy.
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Authors
Heba Bassiony Ghanem
Clinical laboratory sciences Department, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia & Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Marwa Nagy Emam
Physiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Dareen Abdelaziz Mohammed Ali
Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Rania Nagi Abd-Ellatif
Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
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