Analysis of Micro-RNA-۱۴۴ Expression Profile in Patients with Multiple Sclerosis in Comparison with Healthy Individuals
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RBMB-10-3_007
تاریخ نمایه سازی: 25 بهمن 1400
Abstract:
Background: Etiology of multiple sclerosis is non-clarified. It seems that environmental factors impact epigenetic in this disease. Micro-RNAs (MIR) as epigenetic factors are one of the most important factors in non-genetically neurodegenerative diseases. It has been found MIR-۱۴۴ plays a main role in the regulation of many processes in the central nervous system. Here, we aimed to investigation of MIR-۱۴۴ expression alteration in Multiple sclerosis (MS) patients.
Methods: In this study ۳۲ healthy and ۳۲ MS patient's blood sample were analyzed by quantitative Real-Time PCR method and obtained data analyzed by REST ۲۰۰۹ software.
Results: Analysis of Real-Time PCR data revealed that miR-۱۴۴ Increase significantly in MS patients compared to healthy controls. Conclusions: The increase of MIR-۱۴۴ expression in MS patients is obvious. MIR-۱۴۴ can be used as a biomarker of MS and help to early diagnosis and treatment of this disease.
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Authors
Fatemeh Roshani
Department of Genetics, Nourdanesh Institute of higher Education, Myme, Esfahan, Iran.
Hossien Delavar Kasmaee
medical university of Shahid Beheshti, Tehran.
Kowsar Falahati
Medical Genetic Department, National Institute of Genetics Engineering and Biothechnology, Tehran, Iran.
Ghazaleh Arabzadeh
Department of Genetics, Nourdanesh Institute of higher Education, Myme, Esfahan, Iran.
Atefeh Aohan Forooshan Moghadam
Department of Genetics, Nourdanesh Institute of higher Education, Myme, Esfahan,Iran.
Mohammd Hossein Sanati
Medical Genetic Department, National Institute of Genetics Engineering and Biothechnology, Tehran, Iran.
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