Lectin-Like OLR۱ ۳′UTR Rs۱۰۵۰۲۸۶ Gene Polymorphism and Plasma Oxidized-LDL in Coronary Artery Disease and Their Relation to Cardiovascular Risk and Outcomes

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_RBMB-10-4_003

تاریخ نمایه سازی: 25 بهمن 1400

Abstract:

 Background: Oxidized low-density lipoprotein (ox-LDL) has an important role in the genesis of coronary atherosclerosis. Lectin-like ox-LDL receptor ۱ (OLR۱) contributes to the uptake and internalization of ox- LDL. Genetic polymorphisms have been associated with coronary artery disease (CAD). Here we explore the association of plasma levels of ox-LDL and ۳′ UTR OLR۱ (rs۱۰۵۰۲۸۶) SNP with CAD risk and inhospital adverse outcomes. Methods: A case-control study enrolled ۱۹۲ patients with ST-segment elevation myocardial infarction (STEMI), ۱۰۰ patients with unstable angina, and ۱۰۰ healthy controls. Baseline, clinical characteristics, and risk scores of the patients were determined. Plasma ox-LDL and other biochemical variables were measured. All subjects are genotyped for OLR۱ (rs۱۰۵۰۲۸۶) by RT-PCR with TaqMan SNP genotyping assay. Results: Plasma ox-LDL was higher with enhanced sensitivity and specificity in identifying patients with STEMI and was found as a significant independent risk factor for CAD in those two groups. Levels of ox-LDL were increased with increasing poor prognostic factors in STEMI patients that are associated with an increased incidence of some adverse events and in-hospital mortality. Elevated STEMI risk was associated with T allele of OLR۱ (rs۱۰۵۰۲۸۶) (odds ratio of ۴.۹, ۹۵% CI: ۲.۶-۹.۴, p< ۰.۰۰۱). STEMI patients who have T allele exhibited higher risk scores, coronary multivessel narrowing, and elevated incidence of in-hospital major adverse clinical events. Conclusions: These results suggest that plasma ox-LDL, as well as T allele of ORL-۱ (rs۱۰۵۰۲۸۶), is associated with the increased risk for developing STEMI and the associated adverse clinical outcomes.

Authors

Hanan Sharaf El-Deen Mohammed

Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.

Manal Mohamed Kamal

Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Hala Mostafa ElBadre

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Amal Hosni

Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Azza Abo Elfadl

Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Mohamed Ahmed Mostafa

Department of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Reham Ibrahim El-Mahdy

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.

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  • Chen Q, Reis SE, Kammerer C, Craig WY, LaPierre SE, ...
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  • Zhang J, Yin C, Zhang Y, Zhao L, Fu H, ...
  • Morini E, Rizzacasa B, Pucci S, Polidoro C, Ferrè F, ...
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  • Rupprecht HJ, Geeren M, Geeren M, Weilemann S, Schuster HP. ...
  • Maiolino G, Rossitto G, Caielli P, Bisogni V, Rossi GP, ...
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  • Yamashita H, Ehara S, Yoshiyama M, Naruko T, Haze K, ...
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