Mohammad Sadegh Khorrami - Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Metabolic Syndrome
Fatemeh Sadabadi - Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
Alireza Pasdar - Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Hamide Safarian-Bana - Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
Forouzan Amerizadeh - Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Habibollah Esmaeily - Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Department of Epidemiology and Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohsen Moohebati - Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
Alireza Heidari-Bakavoli - Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
Gordon Ferns - Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK.
Majid Ghayour-Mobarhan - Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
Amir Avan - Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Metabolic Syndrome

Background: Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. The Proline and Serine Rich Coiled-Coil ۱ gene in ۱p۱۳.۳ locus has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to investigate the association between the rs۵۹۹۸۳۹ polymorphism of the Proline and Serine Rich Coiled-Coil ۱ (PSRC۱) gene with CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort. Methods: Five hundred and nine individuals who had an average follow-up period of ۱۰ years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method. Results: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= ۴.۷; ۹۵% CI, ۲.۵-۸.۷; p< ۰.۰۰۱) in comparison to those with AA genotype; however, the result was not significant for GG genotype data. Conclusions: The results suggest that the GA/GG genotypes of the PSRC۱gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.

Cardiovascular diseases, cohort studies, Genetic Polymorphism, PSRC۱ gene