Fariba Iraji - Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Behzad Sharif Makhmalzadeh - Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Mahya Abedini - Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Ali Aghaei - Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Amir Siahpoush - Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Objective: Atopic dermatitis (AD) is a common skin disorder with symptoms including severe pruritus and eczematous lesions. AD affects between ۵ and ۲۰% of people in their life. Silymarin (SM) is a polyphenolic flavonoid from Silybum marianum L.  and has several therapeutic characteristics including antiallergic, anticancer, and anti-inflammatory properties. Fumaria officinalis is a small plant that has a high antioxidant power and modulating effects on the immune system. Therefore, the current study intended to examine the influence of these two herbs extract on severity and symptoms of AD in patients.Materials and Methods: ۴۰ patients with mild to moderate eczema randomly received mometasone ۰.۱% or the herbal cream. Treatment course was ۲ weeks and patients were examined before and after ۲ weeks of treatment using the SCORAD system.Results: The reduction of SCORAD score was significant in both groups (p=۰.۰۴ in the herbal group and p=۰.۰۳ in the mometasone group) but no significant difference was observed between the groups. Mean SCORAD score was ۲۷.۶۶±۵.۹ before therapy and ۴.۷۷±۱.۶ after therapy in the mometasone group and mean SCORAD score was ۲۶.۰۵±۷.۱ before therapy and ۶.۹۴۴±۲.۶ after therapy in the herbal group.Conclusion: The current study indicated the impact of these two herbs extract on severity and symptoms of AD in patients; these plants may be a new treatment in reducing eczema symptoms and its problems.

Atopic dermatitis, eczema, Herb, Silymarin, Fumaria officinalis, Silybum marianum