The rs۴۴۱۵۰۸۴ and rs۱۰۹۴۱۶۷۹ Might be Risk Conferring Factors for Breast Cancer among Iranian Women

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
View: 165

This Paper With 6 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

این Paper در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_SGR-8-1_001

تاریخ نمایه سازی: 9 اسفند 1400

Abstract:

Breast cancer is a major cause of cancer-associated death among Iranian women with an increasing trend in breast cancer incidence in recent years. However, few data about genetic determinants associated with breast cancer among Iranian females are available. According to the literature, the genetic variants at the non-coding region of ۵q۱۲ play a critical role in breast cancer susceptibility. Therefore, this study aims to determine the association of rs۴۴۱۵۰۸۴ (T>C) and rs۱۰۹۴۱۶۷۹ (A>G) with breast cancer risk in an Iranian sample population. Peripheral blood samples, taken from ۷۲ patients and ۶۵ controls, were subjected to DNA extraction and genotyping of the mentioned polymorphism by Tetra-primer amplification refractory mutation system PCR (Tetra-ARMS-PCR) assay. Also, the demographic characteristics of the participants were obtained. The results show that the majority of patients had estrogen-receptor (ER) and progesterone-receptor (PR) positive tumors (۷۵% for either receptor) and ۳۶ % were human epidermal growth factor receptor-۲ (HER۲) positive. Also, the majority of the tumors were at T۲ (۵۹.۷ %), N۰ (۴۱.۶ %), and M۰ (۸۶.۱ %) grade. Moreover, a considerable association between the rs۱۰۹۴۱۶۷۹ polymorphism and breast cancer was noticed (p=۰.۰۱) with significantly increased susceptibility of AG genotype. Genotyping of rs۴۴۱۵۰۸۴ also revealed that TC and CC genotypes significantly increased breast cancer risk. This work revealed that the rs۴۴۱۵۰۸۴ and rs۱۰۹۴۱۶۷۹ at ۵q۱۲ might be risk-conferring factors for breast cancer among Iranian women, which could be employed in breast cancer screening and prognosis approaches.

Authors

Hamid Reza Agha Heydar Ali Naghash

Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran

Massoud Hoshmand

National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran

Ali Salehzadeh

Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran

Nafiseh Ansari Nejad

Cancer Pharmacogenetics Research Group (CPGRG), Iran University of Medical Sciences, Tehran, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Colagar AH, Firouzjah HM, Halalkhor S. ۲۰۱۵. Vitamin D receptor ...
  • Easton D, Pooley KA, Dunning AM, Pharoah PD, Thompson D, ...
  • Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J, ...
  • Grigoriadis A, Mackay A, Reis-Filho JS, Steele D, Iseli C, ...
  • Liang H, Li H, Yang X, Chen L, Zhu A, ...
  • Liu S, Patel SH, Ginestier C, Ibarra I, Martin-Trevino R, ...
  • Mcinerney N, Colleran G, Rowan A, Walther A, Barclay E, ...
  • Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, ...
  • Mirzaeyan P, Shokrzadeh M, Salehzadeh A, Ajamian F. ۲۰۲۰. Association ...
  • Nikfarjam A. Pornour M, Sohrabi M, Vaseghi H. ۲۰۱۹. Correlation ...
  • Qin Z, Shen H, Xue J, Jiang Y, Hu Z, ...
  • Ruiz-Narvaez EA, Rosenberg L, Rotimi CN, Cupples LA, Boggs DA, ...
  • Salehiniya H, Haghighat S, Parsaeian M, Majdzadeh R, Mansournia M, ...
  • Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J, ...
  • Stacey SN, Manolescu A, Sulem P, Thorlacius S, Gudjonsson SA, ...
  • Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S, ...
  • Yu Y, Chen Z, Wang H, Zhang Y. ۲۰۱۳. Quantitative ...
  • Zhang Y, Manjunath M, Zhang S, Chasman D, Roy S, ...
  • Zheng W, Wen W, Gao YT, Shyr Y, Zheng Y, ...
  • نمایش کامل مراجع