Comparative investigation to analyse the critical role of NFE۲L۲ gene in heavy metal induced toxicity through in silico approaches

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_EHEM-9-1_005

تاریخ نمایه سازی: 17 اسفند 1400

Abstract:

Background: Accumulation of heavy metals like copper, nickel, arsenic, cobalt, and cadmium are increasing day by day. Accumulation of these heavy metals poses serious threats to human health. Elemental toxicity percentage has been found to be increased day-by-day and creating different minor to major problems from tissue to the gene level. Different important gene expressions are altered due to the contamination of such heavy metals. The present study aimed to identify a common target gene that is involved in the toxicity of major heavy metals and to study the major impact of the gene on the concerned biological system. Methods: In the progression of the work, major genes involved in copper, nickel, arsenic, cobalt, and cadmium toxicity were listed through intense data curation, and a pathway showing the correlation and physical interaction of all the genes that were constructed using in-silico tools STRING and Gene Mania database. Further, functional and expression analysis of the discovered gene was done using in-silico tools like genome-wide association study (GWAS), genotype-tissue expression (GTEx), and RegulomeDB. Results: According to the network analysis, NFE۲L۲ was recognized as a common target involved in the above-mentioned heavy metals toxicity. Expression analysis revealed that the highest expression of NFE۲L۲ was observed in tissues of oesophagus, ovary, bladder, vagina, thyroid, and skin. Detailed investigation at the pathway level revealed that the involvement was importantly observed in immunodeficiency and developmental delay. Conclusion: The study opened a wide vision that the major target of such toxicants is various pathways of neurobiological distress and biological processes, and hence, it can be considered as a susceptible target for heavy metals-induced toxicity.

Authors

Prekshi Garg

Amity Institute of Biotechnology, Amity University, Lucknow, Uttar Pradesh, India

Neha Srivastava

Pharma Analytics Department, Excelra knowledge Solution Pvt Ltd, Hyderabad, Telegana, India

Prachi Srivastava

Corresponding author: Amity Institute of Biotechnology, Amity University, Lucknow, Uttar Pradesh, India

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  • Sytar O, Kumar A, Latowski D, Kuczynska P, Strzałka K, ...
  • Nagajyoti PC, Lee KD, Sreekanth TVM. Heavy metals, occurrence and ...
  • Jaishankar M, Mathew BB, Shah MS, Gowda KRS. Biosorption of ...
  • Kim JJ, Kim YS, Kumar V. Heavy metal toxicity: An ...
  • Morais S, Costa FG, Pereira MDL. Heavy metals and human ...
  • Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal ...
  • Kim HS, Kim YJ, Seo YR. An overview of carcinogenic ...
  • Jacob SE, Goldenberg A, Pelletier JL, Fonacier LS, Usatine R, ...
  • Kupper M, Weinbruch S, Skaug V, Skogstad A, Thorner EE, ...
  • Kim HL, Seo YR. Molecular and genomic approach for understanding ...
  • Chung JY, Yu SD, Hong YS. Environmental source of arsenic ...
  • Raj A, Singh N. Phytoremediation of arsenic contaminated soil by ...
  • Flora SJ. Arsenic-induced oxidative stress and its reversibility following combined ...
  • Patlolla AK, Todorov TI, Tchounwou PB, van der Voet G, ...
  • Baba H, Tsuneyama K, Yazaki M, Nagata K, Minamisaka T, ...
  • James KA, Meliker JR. Environmental cadmium exposure and osteoporosis: a ...
  • Yang O, Kim HL, Weon JI, Seo YR. Endocrine-disrupting chemicals: ...
  • Jahan S, Khan M, Ahmed S, Ullah H. Comparative analysis ...
  • Itoh H, Iwasaki M, Sawada N, Takachi R, Kasuga Y, ...
  • Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, ...
  • Klasson M, Bryngelsson IL, Pettersson C, Husby B, Arvidsson H, ...
  • Simonsen LO, Harbak H, Bennekou P. Cobalt metabolism and toxicologya ...
  • Arnich N, Sirot V, Riviere G, Jean J, Noel L, ...
  • Apel W, Stark D, Stark A, O’Hagan S, Ling J. ...
  • Vasukutty NL, Minhas TH. Systemic effects of cobalt toxicity after ...
  • Midander K, Julander A, Skare L, Liden C. Cobalt skin ...
  • Barceloux DG, Barceloux D. Copper. Journal of Toxicology: Clinical Toxicology ...
  • Gaetke LM, Chow-Johnson HS, Chow CK. Copper: toxicological relevance and ...
  • Taylor AA, Tsuji JS, Garry MR, McArdle ME, Goodfellow WL ...
  • Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, ...
  • Staley JR, Blackshaw J, Kamat MA, Ellis S, Surendran P, ...
  • Mele M, Ferreira PG, Reverter F, DeLuca DS, Monlong J, ...
  • Carithers LJ, Ardlie K, Barcus M, Branton PA, Britton A, ...
  • Sayers EW, Cavanaugh M, Clark K, Ostell J, Pruitt KD, ...
  • Rappaport N, Twik M, Plaschkes I, Nudel R, Iny Stein ...
  • Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, ...
  • Ju Q, Li X, Zhang H, Yan S, Li Y, ...
  • Ma Q. Role of nrf۲ in oxidative stress and toxicity. ...
  • Shadel GS, Horvath TL. Mitochondrial ROS signalling in organismal homeostasis. ...
  • Ribas V, Garcia-Ruiz C, Fernandez-Checa, JC. Glutathione and mitochondria. Frontiers ...
  • Wu KC, Cui JY, Klaassen CD. Beneficial role of Nrf۲ ...
  • Greco T, Shafer J, Fiskum G. Sulforaphane inhibits mitochondrial permeability ...
  • Miyamoto N, Izumi H, Miyamoto R, Kondo H, Tawara A, ...
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