Assessment of Human Leukocyte Antigen Differences between Smokers with Reinke’s Edema and Those with Laryngeal Cancer

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJOTO-34-2_004

تاریخ نمایه سازی: 22 اسفند 1400

Abstract:

Introduction:The present study aimed to assess human leukocyte antigen (HLA) typing differences between smokers with Reinke’s edema and those with laryngeal squamous cell carcinoma (SCC). Materials and Methods:The HLA class I, II alleles were examined in ۷۶ unrelated Iranian patients using low-resolution polymerase chain reaction with the sequence-specific primer (PCR-SSP) method. Results:The frequency of the HLA-A*۳۶ allele and HLA-B*۳۵ was significantly higher in patients with SCC. The frequency of HLA-DRB۱*۰۱ alleles in Reinke’s edema was significantly higher, as compared to that in others. In the volunteer group, HLA-DRB۱*۱۳ and HLA-DRB۱*۱۵ were significantly higher. Conclusions:As evidenced by the obtained results, HLA-A*۳۶ was significantly higher in SCC, as compared to that in volunteers and Reinke’s edema patients. It can be concluded that being positive for HLA-A*۳۶ increases the chance of SCC by three times. This result should be further investigated in cohort studies conducted on larger samples. Furthermore, HLA-A*۲۴ was significantly higher in the volunteer group, as compared to that in other groups. The HLADRB۱*۰۱ was remarkably higher in Reinke’s edema, as compared to that in SCC.

Keywords:

Human leukocyte antigen , Hypertrophic edema , Iranian , Polymerase chain reaction sequence-specific primers , Reinke’s edema

Authors

Farzad Izadi

ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.

Aslan Ahmadi

ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.

Farideh Hosseinzadeh

ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.

Marjan Mirsalehi

ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.

Yadollah Shakiba

Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Mohammad Ali Bahar

Department of Immunology, Iran University of Medical Sciences, Tehran, Iran.

Maryam Balali

ENT and Head and Neck Research Center, the five Senses Health Institute, School of Medicine, Iran University of Medical Sciences.