Maryam Oveissi - Dept. of Infectious Diseases, Clinical Research Development Unit, BuAliSina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
Alireza Nikoonajad - Dept. of Infectious Diseases, Clinical Research Development Unit, BuAliSina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
Abbas Allami - Dept. of Infectious Diseases, Clinical Research Development Unit, BuAliSina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

Background and Objective: Tuberculosis (TB) remains an ongoing major public health problem in the world. In recent years, experimental evidenc suggests a link between TB and Vitamin (Vit) D. This study was conducted to determine serum Vit D, calcium (Ca), phosphorus (P), and parathormone (PTH) levels in untreated pulmonary TB (PTB) patients. Materials and Methods: In this case control study, ۵۰ outdoor PTB patients were selected with ۵۰ gender- matched controls from April ۲۰۱۹ to March ۲۰۲۰. Controls were drawn randomly from general population. Body mass index (BMI) ,serum Vit D, PTH, Ca, P, Albumin (Alb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total and direct bilirubin, blood urea nitrogen (BUN) and creatinine (Cr) levels were measured in the two study groups. The results were analyzed on SPSS version ۲۵. Results: Median [IQR] Vit D levels were ۱۷.۴ [۱۴.۰- ۲۴.۰] ng/ml in cases,and ۲۳.۰ [۱۸.۰- ۲۷.۰] ng/ml in controls (P=۰.۰۰۲). Median [IQR] serum corrected Ca value for the TB patients (۸.۹۱ [۸.۶۰- ۹.۱۵] mg/dL) was significantly lower than that of the healthy controls (۹.۶۰ [۹.۱۵- ۹.۸۹] mg/dL, P< ۰.۰۰۱). Median [IQR] PTH was ۴۸ in TB patients [۴۵- ۵۲ pg/ml ]and ۳۸ in controls [۲۸- ۴۲ pg/ml] (P<۰.۰۰۰۱). Conclusion: BMI and uncorrected and corrected serum Ca, P, Vit D, Alb, and both two aminotransferases levels were significantly lower and serum PTH was significantly higher in patients with TB as compared to controls.

Tuberculosis, Vitamin D, serum Calcium, Parathormone, Aminotransferase