Bicytopenia Secondary to Autoimmune Myelofibrosis as the First Presentation of an Undiagnosed Systemic Lupus Erythematosus: A Rare Case Report
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ZUMS-30-139_015
تاریخ نمایه سازی: 24 اسفند 1400
Abstract:
Autoimmune myelofibrosis (AIMF) is considered as an infrequent cause of bone marrow fibrosis (BMF) and a rare complication of systemic lupus erythematosus (SLE). Due to its rarity, it is mistakenly diagnosed as primary myelofibrosis (MF).
We describe the clinicopathologic features of a secondary form of AIMF in a ۳۳- year- old female patient with an undiagnosed SLE which presented with acute bicytopenia. Absence of splenomegaly, leukopenia, anemia, BMF (grade MF-۱), and presence of autoantibodies were some of noticeable features. Treatment with corticosteroid led to complete regeneration of the bone marrow and subsequently to an improved hematological status. Six- month follow-up showed that the patient was in good clinical condition.
Identification of AIMF is a diagnostic challenge and pitfall and it is actually a diagnosis of exclusion. It could be the first and only presenting feature of SLE and results in hematologic disturbances. So, we should consider SLE-associated AIMF in the differential diagnosis of pancytopenia.
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Authors
Mahdieh Rajabi-Moghaddam
Dept. of Pathology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Gholamali Sarparast
Dept. of Hematology and Oncology, Iranmehr Hospital, Birjand University of Medical Sciences, Birjand, Iran
Hamid Abbaszadeh
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran
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