Nanoencapsulation of n-butanol extract of Symphytum kurdicum and Symphytum asperrimum: Focus on phytochemical analysis, anti-oxidant and antibacterial activity

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-25-3_011

تاریخ نمایه سازی: 15 فروردین 1401

Abstract:

Objective(s): The current study’s objectives were to obtain different extracts and essential oils of Symphytum kurdicum and Symphytum asperrimum and to determine the chemical composition, as well as to evaluate free radical scavenging activity (IC۵۰) and minimum bactericidal concentration (MBC), and the effect of liposomal formulation on antimicrobial properties.Materials and Methods: Air-dried powdered aerial parts of S. kurdicum and S. asperrimum were used. The antioxidant and antibacterial properties, essential oil compositions, total phenol, and flavonoid contents of different fractions were determined by DPPH test, disk diffusion assay, gas chromatography-mass spectrometry, Folin-ciocalteu reagent, and colorimetric assay method, respectively. The film hydration method was used to fabricate nanoparticles.Results: GC-MS analysis indicated that hexafarnesyl acetone was a major essential oil component. n-butanol and ethyl acetate extracts of S. kurdicum had the highest anti-oxidant activity. Extracts of both plants showed antimicrobial activity. The extracts’ maximum inhibition zones against Staphylococcus epidermidis were established. A particle size analyzer detected the formulation size of ۱۴۰ nm. The optimum formulation of liposomes contains the ratio of ۷۵ mg lecithin, ۲۵ mg cholesterol, and ۵۰ mg herbal extract. Despite the nanoparticles’ appropriate particle size, the liposomal extract’s antimicrobial effect was lower than that of the free form.Conclusion: Our findings demonstrated that extracts have significant antibacterial and anti-oxidant activities, attributed to their bioactive constituents.

Authors

Elaheh Mahmoudzadeh

Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Hossein Nazemiyeh

Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Hadi Valizadeh

Research Center for Pharmaceutical Nanotechnology, and Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Farnaz Khaleseh

Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Samin Mohammadi

Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Sanaz Hamedeyazdan

Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

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