Morad Hedayatipanah - Department of Periodontics, Dental Research Centre, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
Leila Gholami - Department of Periodontics, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
Maryam Farhadian - Department of Biostatistics, School of public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Maryam Purjebreil - Department of Periodontics, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
Abbas Farmany - Department of Dental Implant Research & Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

To prevent periodontal diseases and dental caries, the person must remove this layer. In this research study, we aimed at assessing the effectiveness of a spray containing silver nanoparticles/ EDTA/MSM/xylitol compared to the standard mouthwash of ۰.۲% chlorhexidine. This interventional and cross-over clinical trial study was conducted on ۴۰ healthy patients with periodontal diseases and plaque index below ۲۰%. Patients were randomly divided into ۲ groups of ۲۰. Then, the patients in each group were asked not to use other mechanical and chemical substances for one week. Instead, the first group used chlorhexidine mouthwash, and the second group used a spray containing silver nanoparticles/ EDTA/MSM/xylitol. In chlorhexidine mouthwash recipients, there were no signs of gingivitis. In spray recipients, ۷۲.۵% had no visible signs, ۲۵% had a slight change in the color and surface tissue of the gingiva, ۲.۵% had visible inflammation and a tendency to bleed from the margin after probing. None of the recipients had severe inflammation and a tendency to bleed spontaneity in both groups. ۵۰% of chlorhexidine mouthwash recipients and ۳۰% of spray recipients had intervention-induced complications. This research revealed that spray effectively reduced plaque and bleeding, and inflammation of the gingiva. However, its effectiveness was not adequate. But the spray was significantly better than chlorhexidine in reducing teeth staining and the other complications related to chlorhexidine.

dental plaque, anti-plaque spray, nano silver, methyl sulphonyl methane, xylitol, Chlorhexidine ۰.۲%