Quantity and Distribution of Eosinophils in the Adult Human Gastric Specimens

Background & Objective: The existence of eosinophils in the gastric mucosal epithelium is unusual, while the term "eosinophilic gastritis" has become overused due to the increased numbers of eosinophils found in gastric specimens. Thus, we aimed to assess the number and distribution of eosinophils in gastric specimens in Shahid Beheshti University of Medical Sciences hospitals.Methods: This study was performed on ۳۱۸ patients with gastric diseases who had undergone endoscopic biopsy or gastrectomy in the hospitals affiliated with Shahid Beheshti University from ۲۰۱۶ to ۲۰۱۸. By referring to the archives of pathology departments, patients' demographic and clinical information, endoscopic and histopathological findings were collected. The data was then statistically analyzed using SPSS software version ۲۴ with a significance level of P-value< ۰.۰۵ in all tests.Results: The participants were ۱۵۷ men and ۱۶۱ women, with an average age of ۵۱.۲۱ years. There was no significant correlation between eosinophil distribution and age, gender, or primary gastric locations. However, there was a strong correlation between the count of eosinophils in the lamina propria and intestinal metaplasia. Mean eosinophil count per high power field (HPF) was ۱۲, ۲۳, and ۱۴ in mild, moderate, and severe degrees of intestinal metaplasia, respectively. An increase in eosinophil count was seen along with lymphoplasma cells infiltration up to ۸/HPF in mild cases, ۱۳/HPF in moderate cases, and ۱۴/HPF in severe cases.Conclusion: Eosinophil counts in the lamina propria layer show a significant positive relationship with the eosinophil sheet, presence of Heliobacter pylori microorganism, intestinal metaplasia, and lymphoplasma cells infiltration.

Keywords:

Biopsy , Eosinophil , Resection , Stomach