Synthesis and Characterization of Heterocyclic Compounds Derived from ۲-Mercaptobenzothiozole and Study of Their Biological Activities

In this study, Schiff base derivatives were reacted with phenyl isothiocyanate and chloroacetic acid to give diazetidine-۲-thione and oxazolidinone derivatives. The Schiff base derivatives containing the ۲-mercabto benzothiazole moiety were obtained via reaction of a different aromatic aldehyde with ۲-(benzothiazol-۲-ylthio) acetohydrazide. Furthermore, ۲-(benzothiazol-۲-ylthio) acetohydrazide were obtained via reaction of ۲-mercabto benzothiazole with ethyl chloroacetate, then with hydrazine hydrate. The newly synthesized compounds were characterized via spectral data (FT-IR and ۱H-NMR). The antibacterial activity was studied against examples of Gram-positive and Gram-negative bacteria.

Keywords:

Schiff base , حhenyl isothiocyanate , یiazetidine