Adebayo Bale - Department of Chemistry and Industrial Chemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete. P.M.B. ۱۵۳۰, Ilorin, Nigeria
Tolulope Fasina - Department of Chemistry, Faculty of Science, University of Lagos, Akoka, Lagos, Nigeria
Rafiu Shaibu - Department of Chemistry, Faculty of Science, University of Lagos, Akoka, Lagos, Nigeria

۲-methoxy-۲-hydroxychalcone (۲M۲HC) and ۴-methoxy-۲,۴-dichlorochalcone (۴M۲۴DC) and their metal complexes were synthesized, characterised and confirmed by melting point determination, Fourier transform infrared (FT-IR), UV-Visible, ۱H-NMR, EI-MS and AAS spectroscopic techniques. Elemental analysis was carried out and found in agreement with the calculated values. Metal(II) complexes, [M(L۱-۲)۲], [where M = Ni(II), Cu(II), Co(II); L=۲-methoxy-۲-hydroxychalcone (۲M۲HC) and ۴-methoxy-۲,۴-dichlorochalcone (۴M۲۴DC)] were subsequently prepared. The biological evaluation of the synthesized chalcone derivatives and the metal complexes were carried out. The chalcones and their metal complexes were screened for antioxidant (DPPH; ۲,۲-diphenyl-۱-picrylhydrazyl and ABTS; ۲,۲-azino-bis(۳-alkylbenzothiazoline-۶-sulphonic acid) and antimicrobial activities. Overall, the ligands (chalcones) and their metal complexes demonstrated good to moderate antioxidant and antimicrobial activities.

Chalcones, Ligands, Metal complexes, Spectroscopic, Antioxidant, Antimicrobial