Morphine Consumption During Lactation Impairs Short-Term Neuronal Plasticity in Rat Offspring CA۱ Neurons
عنوان مقاله: Morphine Consumption During Lactation Impairs Short-Term Neuronal Plasticity in Rat Offspring CA۱ Neurons
شناسه ملی مقاله: JR_CJNS-8-2_001
منتشر شده در در سال 1401
شناسه ملی مقاله: JR_CJNS-8-2_001
منتشر شده در در سال 1401
مشخصات نویسندگان مقاله:
Fatemeh Aghighi - Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
Mohammad Shabani - Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
Sayyed Alireza Talaei - Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
خلاصه مقاله:
Fatemeh Aghighi - Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
Mohammad Shabani - Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
Sayyed Alireza Talaei - Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
Background: Facing environmental factors during early postnatal life, directly or indirectly via
mother-infant relationships, profoundly affects the structure and function of the mammals’ Central
Nervous System (CNS).
Objectives: This study aimed to evaluate the effect of morphine consumption during the lactation
period on short-term synaptic plasticity of the hippocampal Cornu Ammonis ۱ (CA۱) neurons in
rat offspring.
Materials & Methods: In addition to a group of control mother rats (CO), three groups
subcutaneously received ۵ (M۵), ۱۰ (M۱۰), or ۲۰ (M۲۰) mg/kg morphine every ۱۲ hours during
the lactation period. At ۴۵ days old, following the stimulation of the Schaffers’ collaterals, basic
field Excitatory Post-Synaptic Potentials (fEPSPs) were recorded in their offspring’s hippocampal
CA۱ neuronal circuits. After the construction input/output curve, paired-pulse stimulations with the
inter-stimulus intervals of ۲۰, ۸۰, and ۲۰۰ ms were applied to determine the short-term synaptic
plasticity, and the paired-pulse ratio was evaluated.
Results: The baseline synaptic responses of the rats CA۱ neurons whose mothers received ۱۰ and
۲۰ mg/kg morphine twice daily during the lactation period decreased compared to the CO animals
(P<۰.۰۱ & P<۰.۰۰۱, respectively). Furthermore, compared to the controls, the Paired-Pulse Ratio
(PPR) of the CA۱ neural circuits of M۱۰ and M۲۰ rats at ۲۰ and ۸۰ ms Inter-Stimulus Intervals
(ISI) decreased (P<۰.۰۱).
Conclusion: Morphine exposure during the lactation period has a detrimental impact on the primary
synaptic activity and short-term synaptic plasticity of the hippocampal CA۱ neuronal circuits of
rats’ offspring.
کلمات کلیدی: Morphine, Lactation, Neuronal plasticity, Hippocampus, Rats
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1429037/