Ebrahim Salimi-Sabour - Department of Pharmacognosy and Traditional Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
Mahsa Fattahi - Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
Kamran Rezaei - Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ensieh Lotfali - Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Azadeh Khademian - Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran

Background and Objective: Dermatophytosis is a superficial fungal disease. Prosopis farcta has attracted attention for ethnobotany and medical purposes. The present study aimed to investigate the antifungal properties of Prosopis farcta extracts against Trichophyton mentagrophytes (PTCC ۵۰۵۴) and five archived terbinafine resistant clinical isolates of T. mentagrophyte, based on an ethnobotanical report in Yazd province (Iran). Materials and Methods: In vitro drug susceptibility for methanol extract and amphotericin B was carried out according to the CLSI-M۳۸-A۲. A topical solution (۱%) was formulated by root extract of P. farcta. The nine male Sprague rats were infected by T. mentagrophytes and assessed for in vivo anti-dermatophytic activity. Results: The MIC value of amphotericin B was ≤ ۰.۵ μg/mL against all strains. The methanol extract showed the lowest MIC and MFC values on fungal activity (both with ۰.۰۰۶۲۵ mg/mL). The complete cure of ۲۱-day period with terbinafine is reduced to ۱۰ days with methanol ۸۰% root extract of P. farcta solution. Conclusion: Compared with amphotericin B, P. farcta could be considered a potential antifungal agent in terbinafine-resistant clinical isolates of dermatophytes.

Dermatophytes, Ethnobotanical Report, Prosopis farcta, Terbinafine Resistant, Trichophyton mentagrophytes, درماتوفیت ها, گزارش Ethnobotanical, Prosopis farcta, مقاوم به تربینافین, Trichophyton mentagrophytes