The relationship between postnatal hypoglycemia and umbilical artery Doppler ultrasonography in neonates with intrauterine growth restriction: A longitudinal follow-up study

Abstract Background: Intrauterine growth restriction (IUGR) refers to fetuses with an estimated ultrasonography weight below the ۱۰% percentile. Hypoglycemia is a major concern in neonates with IUGR. Objective: To investigate the relationship between umbilical artery (UA) Doppler ultrasonography and neonate hypoglycemia and IUGR. Materials and Methods: This was a longitudinal follow-up study consisting of ۱۱۴ neonates (gestational age of ۲۸-۴۰ wk) born with IUGR in the third trimester of pregnancy at Shahid Sadoughi Hospital, Yazd, Iran between May ۲۰۱۶ and October ۲۰۱۷. The neonates were assigned into three subgroups of normal UA Doppler, absent end-diastolic flow (EDF) in UA Doppler, and reverse EDF in UA Doppler. The blood glucose of the neonates was checked one, two, three, six, ۱۲, ۲۴ and ۴۸ hr after birth, and the neonates were placed in the hypoglycemia or euglycemia groups according to guidelines. Results: Out of the ۱۱۴ neonates included in the study, ۷۵ (۶۵.۸%) had normal UA Doppler, ۲۹ (۲۵.۴%) had absent EDF in UA Doppler, and ۱۰ (۸.۸%) had reverse EDF in UA Doppler. There was a significant difference in the mean blood glucose in the first hr between the normal UA Doppler group and the reverse EDF in UA Doppler group (p < ۰.۰۱). Conclusion: Postnatal hypoglycemia in neonates with IUGR is associated with the result of UA Doppler ultrasonography during pregnancy.

Keywords:

Growth restriction , Hypoglycemia , Ultrasonography Doppler , Umbilical artery , محدودیت رشد , هایپوگلایسمی , سونوگرافی داپلر , شریان ناف.