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Title

Comparison of the Effectiveness of Metformin with Lifestyle Modification for the Primary Prevention of Type ۲ Diabetes: A Protocol for Systematic Review and Meta-Analysis

دوفصلنامه نظرات نقادانه در علوم زیست پزشکی، دوره: 3، شماره: 1
Year: 1401
COI: JR_CCB-3-1_001
Language: EnglishView: 32
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Authors

Seyedeh Sarah Mousavi - Department of Biostatistics and Epidemiology, School of Public health, Shahid Sadoughi University of Medical Sciences and Health Services, Shohaday-e-Gomnam Blvd., Alem Sq., Yazd, Iran
Seyedeh Mahdieh Namayandeh - Center for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of public health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hossein Fallahzadeh - Center for Healthcare Data Modeling, Departments of biostatistics and Epidemiology, School of Public health, Shahid Sadoughi University of Medical Sciences and Health Services, Shohaday-e-Gomnam Blvd., Alem Sq., Yazd, Iran
Masoud Rahmanian - Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Shohaday-e-Gomnam Blvd., Alem Sq., Yazd, Iran
Mehdi Mollahosseini - Department of Community Nutrition, School of Public health, Shahid Sadoughi University of Medical Sciences and Health Services, Shohaday-e-Gomnam Blvd., Alem Sq., Yazd, Iran

Abstract:

Background: Almost ۹۰% of people with diabetes have type ۲ diabetes and the upward trend of this chronic disease is still ongoing, so that after about four decades, this disease is still one of the top ۱۰ causes of death, while half of these deaths occur in people under ۶۰ years of age. Therefore, prevention is essential and the implementation of the most effective intervention approach is required after recognizing at-risk individuals. This study aimed to evaluate the effect of lifestyle modification interventions and metformin on the prevention of type ۲ diabetes and improvement in four risk factors related to diabetes. Methods: The study was conducted by searching PubMed, Scopus, Web of science, and Google Scholar without time and language restrictions. Randomized controlled trials which examined the effect of both lifestyle modification interventions and metformin in a population over the age of ۱۸ years with no history of any type of diabetes were included. After the withdrawal of poor quality studies and those withfollow-up time of less than ۶ months, structured review and meta-analysis will be performed to calculate the relative risk of type ۲ diabetes incidence and mean difference in weight, body mass index, plasma fasting glucose, and hemoglobin A۱c. Data analysis was performed using comprehensive meta-analysis software version ۲.۲.۰۶۴. Conclusion: This study will make it possible to choose between two conventional therapeutic approaches (lifestyle modification and metformin) to prevent type ۲ diabetes and its impact on four risk factors.

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This Paper COI Code is JR_CCB-3-1_001. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1432445/

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Mousavi, Seyedeh Sarah and Namayandeh, Seyedeh Mahdieh and Fallahzadeh, Hossein and Rahmanian, Masoud and Mollahosseini, Mehdi,1401,Comparison of the Effectiveness of Metformin with Lifestyle Modification for the Primary Prevention of Type ۲ Diabetes: A Protocol for Systematic Review and Meta-Analysis,https://civilica.com/doc/1432445

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  • Organisation WH. news-room/fact-sheets/detail/ diabetes. World Health Organisation; https://www. who.int/news-room/fact-sheets/detail/diabetes. Access ...
  • Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, ...
  • Al Busaidi N, Shanmugam P, Manoharan D. Diabetes in the ...
  • Rev Diabet Stud. ۲۰۱۰;۷:۲۶-۳۵. ۱۰.۱۹۰۰/rds.۲۰۱۰.۷. ۲۶[۸] Anderson JW, Kendall CW, ...
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Type of center: علوم پزشکی
Paper count: 3,390
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