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Title

Morphogenetic Mechanisms of Endothelial Cells During Lumen Formation in Sprouting Angiogenesis

مجله تحقیقات سرطان، دوره: 6، شماره: 2
Year: 1401
COI: JR_MCIJO-6-2_003
Language: EnglishView: 39
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Authors

Mohammad Salar Ghasemi Nasab - Department of Biomedical Engineering, Sahand University of Technology, Tabriz, Iran
Hanieh Niroomand-Oscuii - Department of Biomedical Engineering, Sahand University of Technology, Ta- briz, Iran
Hossein Bazmara - Azad University, Pardis Branch, Tehran, Iran
Majid Soltani - Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran & Advanced Bioengineering Initiative Center, Computational Medicine Center, K. N. Toosi University of Technology, Tehran, Iran & Cancer Biology Research Center, Cance

Abstract:

Different mechanisms such as cell migration, proliferation, branching, anastomosis, and lumen formation occur during the angiogenesis process. Lumen formation is one of the critical mechanisms which is not only necessary for the functional plexus but also for continuing of angiogenesis process. Although multiple studies investigated this mechanism during the angiogenesis process in both in vivo and in vitro conditions, it is not fully understood yet. Different studies have suggested distinctive mechanisms as the main mechanism for lumen formation. Recent studies, however, have shown the fundamental role of blood flow hemodynamics, especially during in vivo lumen formation. This newly introduced mechanism is called ''inverse membrane blebbing''; suggesting that blood pressure causes the formation and expansion of lumen during the in vivo angiogenesis process. This paper reviews cell behavior during lumen formation in the angiogenesis process on a cellular scale.

Keywords:

Paper COI Code

This Paper COI Code is JR_MCIJO-6-2_003. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1439146/

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Ghasemi Nasab, Mohammad Salar and Niroomand-Oscuii, Hanieh and Bazmara, Hossein and Soltani, Majid,1401,Morphogenetic Mechanisms of Endothelial Cells During Lumen Formation in Sprouting Angiogenesis,https://civilica.com/doc/1439146

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