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Title

Comparison of the Therapeutic Effects of Melatonin, Metformin and Vitamin E on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 30، شماره: 140
Year: 1401
COI: JR_ZUMS-30-140_005
Language: EnglishView: 26
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Authors

Ali Akbar Hajiagha Mohammadi - Metabolic Diseases Research Center, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
Sina Khajeh Jahromi - Metabolic Diseases Research Center, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
Somayeh Ahmadi Gooraji - Dept. of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Bastani - Metabolic Diseases Research Center, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

Abstract:

Background and Objective: Currently, no therapeutic or surgical treatment for non-alcoholic fatty liver disease (NAFLD) has been officially approved. This is a serious void in the medical field given the increasing prevalence of NAFLD cases in developing countries. Our study compared the therapeutic effect of metformin, melatonin and vitamin E on serum parameters that are associated with NAFLD pathogenesis. Materials and Methods: This randomized clinical trial was performed on ۱۴۰ patients with NAFLD who were referred to the central hospital of Qazvin. Patients were assigned randomly into four groups. The first group received metformin (۵۰۰mg daily) with two placebos, the second group received melatonin (۱۰mg daily) with two placebos, the third group received daily ۸۰۰ IU vitamin E with two placebos and the fourth group received three placebos daily. All four groups were placed on the same diet regimen and had the same lifestyle changes to increase their daily activity time. Ultrasonography was used for the evaluation of the appearance of liver. Weight, BMI, AST, ALT, lipid profile and FBS were measured at baseline, ۳ months and ۶ months later. Results: All of the therapeutic agents caused a decrease in aminotransferases but metformin was also more potent in improving lipid profiles. A significant difference in LDL was obtained by melatonin (mean change in the control vs. melatonin ۱۵.۹; P=۰.۰۳۲) and AST (mean change in control vs. melatonin -۱۸.۳; P<۰.۰۰۱). Metformin improved liver appearance in ultrasonography imaging better than the other treatments (P=۰.۰۴۳). Conclusion: Metformin can be considered an effective medication but melatonin may accelerate the healing process in NAFLD patients.

Keywords:

Non-alcoholic Fatty Liver Disease , Melatonin , Metformin , Vitamin E.

Paper COI Code

This Paper COI Code is JR_ZUMS-30-140_005. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1439187/

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Hajiagha Mohammadi, Ali Akbar and Khajeh Jahromi, Sina and Ahmadi Gooraji, Somayeh and Bastani, Ali,1401,Comparison of the Therapeutic Effects of Melatonin, Metformin and Vitamin E on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial,https://civilica.com/doc/1439187

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Type of center: علوم پزشکی
Paper count: 996
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