The Relationship between Antioxidants Consumption and Insulin Resistance/Insulin Sensitivity in Type ۲ Diabetes without and with Coronary Stenosis: A Case-Control Study

Background: Type ۲ diabetes (T۲D) is known as a common chronic metabolic disease worldwide. Coronary artery diseases are one of the hazardous disorders in diabetic patients. The current study aimed to investigate the relationship between dietary antioxidants intake with insulin resistance and insulin sensitivity among T۲D without and with coronary stenosis (CS). Methods: This case-control study was conducted on ۲۴۷ participants (۶۵ diabetic patients suffered from CS and ۱۷۲ diabetic patients without CS). Dietary antioxidants intake (vitamin E, Vitamin C, selenium, beta-carotene, and zinc) were assessed with a valid and reliable ۱۶۸-item semi-quantitative food frequency questionnaire (FFQ). Blood pressure, weight, and height were measured. Blood sample was collected for glycaemic control assessment. Results: Diabetic patients with CS had significantly higher HbA۱c levels (P = ۰.۰۰۴). There was a negative significant association between vitamin E (r = -۰.۹۱; P < ۰.۰۰۱) and Beta-carotene (r =-۰.۸۸; P < ۰.۰۰۱) with HbA۱c among all participants. There was also a positive significant association between vitamin E, vitamin C, and selenium with insulin sensitivity among all the participants; (r = ۰.۵۹; P = ۰.۰۰۴) for vitamin E, (r = ۰.۹۱; P < ۰.۰۰۱) for vitamin C, and (r = ۰.۲۷; P = ۰.۰۴) for Beta-carotene. Conclusion: Antioxidants intake especially vitamin C and beta-carotene may have an anti-insulin resistance effect in metabolic disorders

Keywords:

Diabetes mellitus , Coronary stenosis , Dietary intake , Antioxidants , Insulin resistance