The Regulatory Role of Differential Expressed MicroRNAs and Viral Oncoproteins in Angiogenesis of Human Papillomavirus-Related Cancer

According to the performed study, the most important known cause of cervical cancer is contamination with HPV infection which is the main cause known for complex molecular changes leading to the neck epithelial cells, and if the virus is of the high risk type, it leads to cervical cancer. Studies and analysis of performed experiments, have led to the belief that some miRNAs play a key role in cancer prognosis and the evaluation of them can indicate the existence of cervical cancer. Analysis results indicate that in cervical cancer, some oncoproteins such as E۵, E۶, and E۷, begin their activity when the HIV infection starts. Each of these oncoproteins have various functions. They can cause disorders or performance improvements. The present paper provides a brief review of these oncoproteins as well as miRNAs involved in cervical cancer.

Keywords:

Cervical cancer , HPV , E۶ and E۷ , P۵۳ , Angiogenesis