Mohammad Reza Zinatizadeh - Department of Genetics, Faculty of Science, Tonekabon Branch, Islamic Azad University, Mazandaran, Iran
Zahra Masoumalinejad - Department of Microbiology, Science and Research Branch, Islamic Azad University, Sirjan, Iran
Farzaneh Parnak - Department of Microbiology, Science and Research Branch, Islamic Azad University, Sirjan, Iran

Infectious agents cause ۱۵-۲۰% of cancers worldwide. The infectious agents and contamination may be caused by a local chronic and advanced local inflammatory response, or by tumorization. Mycoplasma contamination can interfere with biological agents and cause DNA damage which affects gene expression, and disrupts the control of cell cycle inspection and apoptotic responses. Mycoplasmas are widely distributed in nature; some mycoplasmas have the ability to penetrate into the cell and cause severe disease. Most mycoplasmas are known to infect the cell culture media, which is difficult to detect and contaminate. M. hyorhinis is one of the causes of Mycoplasma contamination in tissues samples from cancer patients. Mycoplasma is related with human cancers and several other human diseases. Several studies have shown that the potential role of M. hyorhinis includes esophageal, gastric, lung, breast, glioma, colon, and prostate cancers. The prevalence of M hyorhinis in various tissues leads to cancer progression. Therefore, it is necessary to pay more attention to this mycoplasma agent in order to control and understand its mechanism.  

M. hyorhinis, cancer, gastric, breast, lung