Relevant Allelic Frequency of Gene Polymorphism and Genetic Predisposition of Human Papillomavirus in Patients with Cervical Cancer

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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JR_MML-1-2_002

تاریخ نمایه سازی: 25 اردیبهشت 1401

Abstract:

Backround: The present study investigated the correlation between p۵۳ gene codon ۷۲ polymorphism and ۶ other genetic single nucleotide polymorphisms (SNPs) in patients with cervical cancer infected by HPV. Methods: ۴۵۰ patients with cervical cancer (۲۸۰ Squamous cell carcinoma and ۱۷۰ Adenocarcinoma) were followed at hospitals in Iran from Dec. ۲۰۱۴ to Apr. ۲۰۱۵. Moreover, ۱۰۰ age/sex-matched were used as the control group. HPV was detected by LINEAR ARRAY® HPV Genotyping Test. Allelic frequency of ۶ gene polymorphisms was detected by the amplification-refractory mutation system (ARMS). Results: From ۴۵۰ patients, ۴۰۸ cases (۹۰.۶۶%) were positive for HPV. Four genotypes were observed as single infections (۱۶, ۱۸, ۳۱, and ۴۵). The most common genotypes were HPV-۱۶ (۷۳.۵۲%), HPV-۱۸ (۲۳.۲۸%), HPV-۳۱ and ۴۵ (۳.۱۷%), respectively. ۳۰۶ samples were arginine-arginine homozygous (۷۰.۶% and ۷۱.۴% of adenocarcinoma and squamous cell carcinoma, respectively), ۷۰ cases were arginine-proline heterozygous (۱۷.۶% of adenocarcinoma and ۲۳.۸% of squamous cell carcinoma), and ۲۰ cases were as proline-proline homozygous (۱۱.۸% and ۴.۸% of adenocarcinoma and squamous cell carcinoma, respectively). Conclusion: The prevalence of HPV was ۸۴% and that was the estimation of the Global Burden among Iranian patients with cervical cancer (۸۵% - ۹۹%). There was no correlation between mutations in the p۵۳ allele and the size/type of tumors, while we found a correlation between mutations in p۵۳ alleles and age. Therefore, XRCC۱ G۳۹۹A SNP and TP۵۳ G۷۲C SNP were significantly correlated with the cervical cancer. Abbreviations: HPV: Human papillomavirus; SNP: Single nucleotide polymorphism; CDKN۱A: cycling-dependent kinase inhibitor ۱A; TP۵۳: Tumor protein p۵۳ (also known as p۵۳); P۵۳c۷۲: p۵۳ gene codon ۷۲; ATM: Ataxia-telangiectasia mutated; HDM۲: Human double minutes ۲ (also known as MDM۲); LIG۴: DNA ligase IV; XRCC۱: X-ray repair cross-complementing ۱; XRCC۳: X-ray repair cross-complementing ۳; TGFB۱: Transforming Growth Factor Beta ۱; HWE’: Hardy-Weinberg equilibrium; FIGO stage: International Federation of Gynecology and Obstetrics tumor stage; 

Authors

Nikta Sajjadi

CBMA, Centre of Molecular and Environmental Biology Department of Biology, University of Minho Campus of Gualtar, Braga, Portugal

Reza Mirnejad

Molecular Biology Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran

Malike Sharif

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Vahhab Piranfar

Department of Biology, Farname Inc, Thornhill, ON, Canada

Davood Zaeifi

Department of Biology, North-Tehran Branch , Islamic Azad University, Tehran, Iran

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