Mahdi Atabaki - Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
Zhaleh Shariati-Sarabi - Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Jalil Tavakkol-Afshari - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Ali Taghipour - Department of Epidemiology, Social Determinants of Health Research Center, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmood Reza Jafari - Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Amin Reza Nikpoor - Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Mojgan Mohammadi - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Objective: Osteoarthritis is the most common disease in the group of joint diseases, and its incidence is directly related to aging. Given the anti-inflammatory effects of curcumin as an active ingredient of turmeric, we aimed to investigate the effects of this compound in a new curcumin nanomicelle formula named SinaCurcumin® on the expression of microRNAs (miRNAs) involved in immune responses of patients with osteoarthritis.Materials and Methods: We divided ۳۰ patients with osteoarthritis into two groups namely, nano curcumin-receiving (۱۵ patients) and placebo-receiving (۱۵ patients) and we studied them for ۳ months. The Iranian Registry of Clinical Trials (IRCT) approved our study with the IRCT registry No. IRCT۲۰۱۵۱۰۲۸۰۲۴۷۶۰N۴. We evaluated the rates of the expression of microRNAs ۱۴۶, ۱۵۵, ۱۶, and ۱۳۸ employing SYBR Green Real-Time PCR method.Results: The expression of miRNAs ۱۵۵, ۱۳۸, and ۱۶ revealed a significant reduction in the curcumin-receiving group (p=۰.۰۰۲, p=۰.۰۲۴ and p=۰.۰۰۰۱ respectively).Conclusion: Our research data indicated that the consumption of curcumin in patients with osteoarthritis could affect the immune system partially via altering the expression of microRNAs and cytokines.

Curcumin, MiR-۱۴۶, MiR-۱۵, MiR-۱۳۸, MiR-۱۶, Osteoarthritis