Appropriateness of Sildenafil Prescribing in Pulmonary Hypertension with Valvular Heart Disease: A Single Centre Study
Publish place: Trends in Pharmaceutical Sciences، Vol: 8، Issue: 1
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 28 اردیبهشت 1401
Abstract:
Oral sildenafil has proven efficacy in pulmonary hypertension in current clinical practice. However, there is a research gap in sildenafil prescribing among patients with valvular heart disease (VHD) and pulmonary hypertension (PH) in Malaysia. This study aimed to determine the appropriateness of sildenafil prescribing and rehospitalization rate in patients with corrected VHD and PH. This is a retrospective descriptive study using universal sampling with a calculated sampling size of ۱۲۳. Patients who were diagnosed with VHD and PH in Hospital Serdang were recruited from ۲۰۱۴ - ۲۰۱۸. Patients' demographic and clinical characteristics were retrieved from Electronic Hospital Information System (eHIS) and recorded using a pre-designed data collection form. Appropriateness prescribing of sildenafil included appropriate dose(۲۰mg to ۸۰mg three times daily) and duration(total of eight weeks of sildenafil treatment that started before and continued after surgery). Rehospitalization is defined as any hospitalization within six months after surgery. Data were analyzed using descriptive and inferential statistics. From ۱۲۳ patients (۴۴.۷% male, ۵۵.۳% female), ۴۱% (n=۵۱) and ۶۱.۸%(n=۷۶) received appropriate dose and duration of Sildenafil respectively. Rehospitalization rate within six months after valve surgery was ۵۵.۳%(n=۶۸). Univariate analysis showed that patients more than ۶۵ years old (p=۰.۰۳۹), atrial fibrillation (AF) (p=۰.۰۴) and female (p=۰.۰۰۲) received appropriate prescribing of sildenafil. Only female patients and patients with AF were the predictors of appropriate prescribing of sildenafil. The role of sildenafil in VHD and PH remains unclear and needs further research in different perspectives such as short term and long-term duration with different doses.
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Authors
Tze Hoon Goo
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
Farizan Abdul Ghaffar
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
Wardati Mazlan Kepli
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
Nur Atiqah Zulkifli
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
Yen Chie Lim
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
Chen Wei Cheng
Pharmacy Department, Serdang Hospital, Selangor, Malaysia
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