Micro Spectrophotometric Determination and Cloud Point Extraction of Aspirin with Iron (III) in Pure Form and Pharmaceutical Drugs

Cloud-point extraction and molecular spectrophotometry in tandem was developed and suggested as a method for detecting aspirin and iron (III) ions in pharmaceutical. In a dilute acidic medium, aspirin interacted with Fe(III) ions to produce a brightly colored [Fe(III)-aspirin] complex, which was originally as a mediated extractant, extracted into Triton X-۱۱۴ micelles, then determined by spectrophotometry at a wavelength maximum of ۵۲۷ nm. For target analytes, all experimental variables were previously adjusted to accomplish this purpose. The results showed that pre-concentration factors of ۸۰ for aspirin resulted in a detection limit of ۰.۲۳ g mL-۱ having a linear range of (۵-۱۲۰) gmL-۱ (r= ۰.۹۹۹۸). For aspirin, a mean recovery percentage of ۹۸. ± ۱.۰۹% was recorded, with precision (RSD %) ranging from ۰.۰۴-۰.۶۶ %.

Keywords:

aspirin , Spectrophotometry , Ferric Ion , Cloud Pint Extraction