Association of Exposure to Polycyclic Aromatic Hydrocarbons with Inflammation, Oxidative DNA Damage and Renal-pulmonary Dysfunctions in Barbecue Makers in Southern Nigeria

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_RBMB-11-1_009

تاریخ نمایه سازی: 16 خرداد 1401

Abstract:

Background: Multiple organ dysfunctions have been linked to exposure to polycyclic aromatic hydrocarbons (PAH) and oxidative stress (OS), oxidative DNA damage, and inflammatory response to PAH have been implicated. The biomarkers of OS (malondialdehyde (MDA), total plasma peroxide (TPP), total antioxidant capacity (TAC), glutathione (GSH), nitric oxide (NO), oxidative stress index (OSI)); ۸-hydroxy-۲-deoxyguanosine (۸-OHdG)); tumor necrosis factor-alpha (TNF-α)); ۱-hydroxy pyrene (۱-HOP)), serum and urine creatinine, uric acid (UA), estimated glomerular filtration rate (eGFR) and peak expiratory flow rate (PEFR) were assessed in barbecue makers. Methods: One hundred barbecue makers and ۵۰ controls were enrolled into the study. Serum and urine creatinine, UA, TAC, MDA, GSH, NO and TPP were estimated by colorimetry, ۸-OHdG and TNF-α by ELISA, PEFR using peak flow meter, ۱-HOP by HPLC, eGFR and OSI by calculation. Results: Barbecue makers had lower TAC, PEFR, and higher TNF-α and OS compared to controls (P<۰.۰۵). Higher TNF-α, lipid peroxidation, and lower antioxidants were observed in barbecue makers who had worked for >۵years compared to <۵years (P<۰.۰۵). Increasing number of working hours was associated with higher NO, lipid peroxidation, OS and lower antioxidants in barbecue makers (P<۰.۰۵). Positive associations were observed between ۱-HOP and TPP (r=۰.۵۷۰, P=۰.۰۰۰), OSI (r=۰.۲۹۹, P=۰.۰۳۵) and negative association between TAC and TNF-α (r=-۰.۲۰۹, P=۰.۰۳۷), MDA (r=-۰.۲۶۵, P=۰.۰۰۸) in barbecue makers. Conclusion: Increased lipid peroxidation, OS, inflammation and depressed antioxidants and lung function observed in barbecue makers suggest increased risk of chronic lung conditions which may be associated with exposure to PAH in barbecue fumes. 

Authors

Augusta Chinyere Nsonwu-Anyanwu

Department of Medical Laboratory Science, University of Calabar, PMB ۱۱۱۵, Calabar, Nigeria.

Augusta Ndudi Idenyi

Department of Medical Laboratory Science, University of Calabar, PMB ۱۱۱۵, Calabar, Nigeria.

Sunday Jeremiah Offor

Department of Medical Laboratory Science, University of Calabar, PMB ۱۱۱۵, Calabar, Nigeria.

Caroline Chinenyenwa Thomas

Department of Medical Laboratory Science, University of Calabar, PMB ۱۱۱۵, Calabar, Nigeria.

Friday Okputu

Department of Medical Laboratory Science, University of Calabar, PMB ۱۱۱۵, Calabar, Nigeria.

Clement Emmanuel Edet

Department of Medical Laboratory Science, University of Calabar, PMB ۱۱۱۵, Calabar, Nigeria.

Chinyere Adanna Opara Usoro

Department of Medical Laboratory Science, University of Calabar, PMB ۱۱۱۵, Calabar, Nigeria.

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  • Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. ۱۹۷۸;۵۲:۳۰۲- ...
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