Electromechanical modeling and simulation of the physiological state of human gastric wall smooth muscle cells

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_CSE-2-1_002

تاریخ نمایه سازی: 17 خرداد 1401

Abstract:

Electromechanical and regular contractions of the smooth muscles of the gastric wall are responsible for grinding, mixing, and propulsion food into the intestines. Lack of proper functioning in contracting the smooth muscle causes digestive disorders. This study aimed to present an electromechanical model for the contraction of smooth muscles of the human gastric wall in the physiological state. In this model, the electromechanical contraction of the smooth muscles is due to the distribution of the electrophysiological slow wave (Due to ionic interaction of cells with extracellular environment and adjacent cells) over ۲۴۰ cells and ۵۴۸ links. The results showed that the contraction started at the beginning of the gastric wall and gradually transferred to the end of the wall (pylorus). Also, it was found that the maximum contraction of about ۳۴.۷% occurs at the end of the model and near the pyloric sphincter. Finally, the behavior of tissues can be simulated non-invasively using the modeling and their function can be examined under physiological and pathological conditions.

Authors

Hossein Taghadosi

Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Farhad Tabatabai Ghomsheh

Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Aydin Farajidavar

Department of Electrical and Computer Engineering, New York Institute of Technology, Old Westbury, New York, USA.

Faezeh Khazaee

Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Fatemeh Hoseinpour

Department of Occupational Therapy, Semnan University of Medical Science, Semnan, Iran.

Zahra Beshkooh

Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.