Sepideh Rezaei - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism ‎Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Sholeh Akbari - Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Farzad Rahmani - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Sara Dabbaghi Varnousfaderani - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism ‎Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Saeideh Gomroki - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism ‎Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Emad Jafarzadeh - Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Introduction: Bacterial infection and the growing resistance of the bacteria to drugs is a global issue which challenges the health system. Therefore, the development of drugs with a different mechanism of action is a reasonable approach to overcome the drug resistance. Nitrofurans are antibacterial agents with broad-spectrum effects on various types of bacteria. In the present study, we aimed to review the reported derivatives of nitrofurans with antibacterial impacts to evaluate the potency and efficiency of these agents as candidates for antibacterial drug development.Methods: A systematic literature search was performed on April ۲۰۲۱ in databases using “Nitrofurans” and “antibacterial” as the keywords using all their equivalents, similar terms, and known forms. The search was first limited to original articles in the English language, and all the relevant articles were included for data extraction. The main outcomes in all the included studies were antibacterial efficacy and bactericidal power. Results: Overall, ۳۶ articles were found and used for data extraction. Findings showed that nitrofuran-based compounds have satisfactory antimicrobial effects at the micromolar level. Most of these agents also revealed high efficacy on gram-positive and gram-negative bacteria with minimal toxicity on human cells. Findings suggested that chemical modification of nitrofurans with appropriate functional groups and molecules can enhance the efficiency of these agents.Conclusion: According to the included studies, nitrofuran and its derivatives can be considered promising candidates for future drug discovery to combat drug-resistant bacteria.

Nitrofurans, Bacterial infection, Antimicrobial, Drug resistance