Development of a new quantification method using partial volume effect correction for individual energy peaks in ۱۱۱In-pentetreotide SPECT/CT

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JNMB-10-2_006

تاریخ نمایه سازی: 21 خرداد 1401

Abstract:

Objective(s): Somatostatin receptor scintigraphy (SRS) using ۱۱۱In-pentetreotide has no established quantification method. The purpose of this study was to develop a new quantitative method to correct the partial volume effect (PVE) for individual energy peaks in ۱۱۱In-pentetreotide single-photon emission computed tomography (SPECT).Methods: Phantom experiments were performed to construct a new quantitative method. In the phantom experiments, a NEMA IEC body phantom was used. Acquisition was performed using two energy peaks (۱۷۱ keV and ۲۴۵ keV) on the SPECT/CT system. The volume of interest was set at each hot sphere and lung insert in the SPECT images of each energy peak, and the recovery coefficient (RC) was calculated to understand the PVE. A new quantitative index, the indium uptake index (IUI), was calculated using the RC to correct the PVE. The quantitative accuracy of the IUI in the hot sphere was confirmed. Case studies were performed to clarify the quantitative accuracy. In a case study, the relationship between the IUI and the Krenning score, which is used as a visual assessment, was evaluated for each lesion.Results: The obtained RCs showed that the energy peak at ۱۷۱ keV was faster in recovering the effect of PVE than that at ۲۴۵ keV. The IUI in the ۱۷-mm-diameter hot sphere was overestimated by ۴.۸% and ۸.۳% at ۱۷۱ keV and ۲۴۵ keV, respectively, compared to the actual IUIs. The relationship between IUI and Krenning score was rs=۰.۷۷۳ (p<۰.۰۰۵) at sum, rs=۰.۷۳۹ (p<۰.۰۰۵) at ۱۷۱ keV, and rs=۰.۷۷۳ (p<۰.۰۰۵) at ۲۴۵ keV.Conclusion: We have developed a new quantification method for ۱۱۱In-pentetreotide SPECT/CT using RC-based PVE correction for an individual energy peak of ۱۷۱ keV. The quantitative accuracy of this method was high even for accumulations of less than ۲۰ mm, and it showed a good relationship with the Krenning score; therefore, the clinical usefulness of IUI was demonstrated.

Keywords:

Single photon emission computed tomography (SPECT) , ۱۱۱In-pentetreotide , somatostatin receptor scintigraphy (SRS) , Indium Uptake Index (IUI) Partial Volume Effect (PVE)

Authors

Kosuke Yamashita

Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan

Noriaki Miyaji

Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan

Kazuki Motegi

Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan

Takashi Terauchi

Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan

Shigeki Ito

Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

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